Extravasation and Interstitial Transport in Tumors
The use of high-molecular-weight agents such as proteins has been of increasing interest for cancer detection and treatment since the development of genetic engineering and hybridoma technology. These agents include monoclonal antibodies (conjugated with radionuclides, toxins, cytokines, or enzymes), growth factors, biological response modifiers, and enzymes. The use of cells, such as lymphokine-activated killer cells or tumor-infiltrating lymphocytes, is also being investigated. The potent toxicity of some of these agents toward cancer cells in vitro has ignited hopes for a “magic bullet.” Although these agents show great potential, results in clinical studies have not been so positive.
KeywordsPermeability Coefficient Fluorescence Recovery After Photobleaching Interstitial Pressure Fluid Filtration Interstitial Diffusion
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- Curry, F. E., 1984, Mechanics and thermodynamics of transcapillary exchange, in: Handbook of Physiology, Section 2 (E. M. Renkin and C. C. Michel, eds.), American Physiological Society, Bethesda, pp. 309–374.Google Scholar
- Curry, F. E., Mason, J. C., and Michel, C. C., 1976, Osmotic reflection coefficients of capillary walls to low molecular weight hydrophilic solutes measured in single perfused capillaries of the frog mesentery, J. Physiol. (London) 261:319–336.Google Scholar
- Misiewicz, M. A., 1986, Microvascular and interstitial pressure in normal and neoplastic tissues, M.S. thesis, Carnegie Mellon University, Pittsburgh.Google Scholar
- O’Conner, S. W., and Bale, W. F., 1984, Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors, Cancer Res. 44:3719–3723.Google Scholar
- Rutili, G., 1978, Transport of macromolecules in subcutaneous tissue by FITC-dextrans, Ph.D. thesis, University of Upsaliensis, Uppsala, Sweden.Google Scholar
- Stickney, D. R., Slater, J. B., Kirk, G. A., Ahlem, C., Chang, C., and Frincke, J. M., 1989, Bifunctional antibody: ZCE/CHA-indium-111-BLEDTA-IV clinical imaging in colorectal carcinoma, Antibody Immunoconjugates Radiopharm. 2:1–13.Google Scholar
- Weinstein, J. N., Steller, M. A., Keenan, A. M., Covell, D. G., Key, M. E., Sieber, S. M., Oldham, R. K., Hwang, K. M., and Parker, R. J., 1983, Monoclonal antibodies in the lymphatics: Selective delivery to lymph node metastases of a solid tumor, Science 222: 423-426.Google Scholar
- Yuan, F., Leunig, M., Berk, D., and Jain, R. K., 1993, Microvascular permeability of albumin in human tumor xenograft LS174T in dorsal skin fold chamber of SCID mice, Microvasc. Res. (in press).Google Scholar