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Extravasation and Interstitial Transport in Tumors

  • Rakesh K. Jain
  • Laurence T. Baxter
Part of the Pharmaceutical Biotechnology book series (PBIO, volume 4)

Abstract

The use of high-molecular-weight agents such as proteins has been of increasing interest for cancer detection and treatment since the development of genetic engineering and hybridoma technology. These agents include monoclonal antibodies (conjugated with radionuclides, toxins, cytokines, or enzymes), growth factors, biological response modifiers, and enzymes. The use of cells, such as lymphokine-activated killer cells or tumor-infiltrating lymphocytes, is also being investigated. The potent toxicity of some of these agents toward cancer cells in vitro has ignited hopes for a “magic bullet.” Although these agents show great potential, results in clinical studies have not been so positive.

Keywords

Permeability Coefficient Fluorescence Recovery After Photobleaching Interstitial Pressure Fluid Filtration Interstitial Diffusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Rakesh K. Jain
    • 1
  • Laurence T. Baxter
    • 1
  1. 1.Department of Radiation Oncology, Harvard Medical School, Steele LaboratoryMassachusetts General HospitalBostonUSA

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