Extravasation and Interstitial Transport in Tumors
The use of high-molecular-weight agents such as proteins has been of increasing interest for cancer detection and treatment since the development of genetic engineering and hybridoma technology. These agents include monoclonal antibodies (conjugated with radionuclides, toxins, cytokines, or enzymes), growth factors, biological response modifiers, and enzymes. The use of cells, such as lymphokine-activated killer cells or tumor-infiltrating lymphocytes, is also being investigated. The potent toxicity of some of these agents toward cancer cells in vitro has ignited hopes for a “magic bullet.” Although these agents show great potential, results in clinical studies have not been so positive.
KeywordsPermeability Toxicity Filtration Convection Albumin
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