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Antigenicity of Soybean Protease Inhibitors

  • Chapter
Protease Inhibitors as Cancer Chemopreventive Agents

Abstract

Trypsin inhibitors (TIs) constitute at least 6% of the protein of soybeans (Ryan, 1973). In addition to their beneficial effects elaborated upon in this volume, high levels of protease inhibitors have both antinutritional and toxicological effects (reviewed by Gallaher and Schneeman, 1984; Rackis and Gumbmann, 1981). In the rat, dietary protease inhibitors can induce the development of pancreatic acinar cell adenoma, but the mechanistic basis, involving cholecystokinin, appears not to operate in other species, including humans (see Chapter 18). Accurate measurement of specific protease inhibitors will be important to define the human dietary exposure to protease inhibitors in epidemiological studies. Such studies should elucidate the role of protease inhibitors in preventing breast, colon, and prostatic cancer, as well as their potential contribution to human pancreatic cancer (see Chapters 1 and 18).

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Author information

Authors and Affiliations

  1. Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, California, 94710, USA

    David L. Brandon, Anne H. Bates & Mendel Friedman

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  1. David L. Brandon
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  2. Anne H. Bates
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  3. Mendel Friedman
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Editor information

Editors and Affiliations

  1. Department of Environmental Medicine, New York University Medical Center, New York, New York, 10016, USA

    Walter Troll

  2. Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Ann R. Kennedy

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Brandon, D.L., Bates, A.H., Friedman, M. (1993). Antigenicity of Soybean Protease Inhibitors. In: Troll, W., Kennedy, A.R. (eds) Protease Inhibitors as Cancer Chemopreventive Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2882-1_6

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  • DOI: https://doi.org/10.1007/978-1-4615-2882-1_6

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