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Transcription Factor Crem: A Key Element of the Nuclear Response to cAMP

  • Denis Masquilier
  • Brid M. Laoide
  • Véronique Delmas
  • Rolf P. de Groot
  • Nicholas S. Foulkes
  • Enrico Benusiglio
  • Carlos A. Molina
  • Florence Schlotter
  • Paolo Sassone-Corsi
Part of the NATO ASI Series book series (NSSA, volume 246)

Abstract

A prerequisite for normal cell growth and differentiation is that each cell must be able to receive, interpret and respond appropriately to signals from other cells and the environment. The plasma membrane is the external interface of the cell and bears many elements which are required for the primary analysis of such signals. Among these elements are membrane receptors which are able to interact specifically with a variety of compounds. Binding of a ligand to its receptor initiates a cascade of events which modulate a variety of cellular functions including the control of gene expression. By altering the spectrum of genes expressed, the cell appropriately modifies its physiology for a given stimulus. Aberrations in this process can lead to deregulated cell proliferation and ultimately tumorigenesis.

Keywords

Leucine Zipper Pachytene Spermatocyte cAMP Signal Transduction Pathway Transcriptional Activator CREB CREM Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Auwerx, J., and Sassone-Corsi, P., 1991, IP-1: a dominant inhibitor of Fos/Jun whose activity is regulated by phosphorylation. Cell 64: 983.PubMedCrossRefGoogle Scholar
  2. Berkowitz, L.A, Riabowol, K.T., and Gilman, M.Z., 1989, Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol. Cell. Biol. 9: 4272.PubMedGoogle Scholar
  3. Borrelli, E., Montmayeur, J.P., Foulkes, N.S., and Sassone-Corsi, P., 1992, Signal transduction and gene control: the cAMP pathway. Critical Rev Oncogenesis 3: 321.Google Scholar
  4. Busch, S.J., and Sassone-Corsi, P., 1990, Dimers, leucine zippers and DNA binding domains. Trends Genet. 6: 36.PubMedCrossRefGoogle Scholar
  5. Comb, M., Birnberg, N.C., Seasholtz, A., Herbert, E., and Goodman, H.M., 1986, A cyclic-AMP and phorbol ester-inducible DNA element. Nature 323: 353.PubMedCrossRefGoogle Scholar
  6. deGroot, R.P., and Sassone-Corsi, P., 1992, Activation of Jun/AP-1 by protein kinase A. Oncogene 7: 2281.Google Scholar
  7. Delegeane, A., Ferland, L., and Mellon, P.L., 1987, Tissue specific enhancer of the human glycoprotein hormone α-subunit gene: dependence on cyclic AMP-inducible elements. Mol. Cell. Biol. 7: 3994.PubMedGoogle Scholar
  8. Delmas, V., Laoide, B.M., Masquilier, D., de Groot, R.P., Foulkes, N.S., and Sassone-Corsi, P., 1992, Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator (CREM) generates regulators with opposite functions. Proc Natl Acad Sei USA 89: 4226.CrossRefGoogle Scholar
  9. Deutsch, P.J., Hoeffler, J.P., Jameson, J.L. and Habener, J.F., 1988, Cyclic AMP and phorbol esterstimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc. Natl. Acad. Sci. USA. 85: 7922.PubMedCrossRefGoogle Scholar
  10. Foulkes, N.S., Borrelli, E., Sassone-Corsi, P., 1991a, CREM gene: use of alternative DNA binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64: 739.PubMedCrossRefGoogle Scholar
  11. Foulkes, N.S., Laoide, B.M., Schlotter, F., and Sassone-Corsi, P., 1991b, Transcriptional antagonist CREM down-regulates c-fos cAMP-induced expression. Proc. Natl. Acad. Sci. USA 88: 5448.PubMedCrossRefGoogle Scholar
  12. Foulkes, N.S., Mellström, B., Benusiglio, E., and Sassone-Corsi, P., 1992, Developmental switch of CREM function during spermatogenesis: from antagonist to transcriptional activator. Nature 355: 80.PubMedCrossRefGoogle Scholar
  13. Foulkes, N.S., and Sassone-Corsi, P., 1992, More is better: activators and repressors from the same gene. Cell 68: 411.PubMedCrossRefGoogle Scholar
  14. Gonzalez, G.A., Menzel, P., Leonard, J., Fischer, W.H., and Montminy, M.R., 1991, Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol. Cell. Biol. 11: 1306.PubMedGoogle Scholar
  15. Gonzalez, G.A., Yamamoto, K.K., Fischer, W.H., Karr, K., Menzel, P., Briggs, III W., Vale, W.W., and Montminy, M.R., 1989, A cluster of phosphorylation sites on the cAMP-regulated nuclear factor CREB predicted by its sequence. Nature 337: 749.PubMedCrossRefGoogle Scholar
  16. Gonzalez, G.A., and Montminy, M.R., 1989, Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at ser 133. Cell 59: 675.PubMedCrossRefGoogle Scholar
  17. Habener, J., 1990, Cyclic AMP response element binding proteins: a cornucopia of transcription factors. Mol. Endocrionol. 4: 1087.CrossRefGoogle Scholar
  18. Hai, T.-Y., and Curran, T., 1991, Cross-family dimerization of transcription factors Fos: Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88: 3720.PubMedCrossRefGoogle Scholar
  19. Hai, T.-Y., Liu, F., Coukos, W.J., and Green, M.R., 1989, Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA binding heterodimers. Genes & Dev. 3: 2083.CrossRefGoogle Scholar
  20. Hoeffler, J.P., Meyer, T.E., Yun, Y., Jameson, J.L., and Habener, J.F., 1988, Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242: 1430.PubMedCrossRefGoogle Scholar
  21. Hoeffler, J.P., Lustbader, J.W., and Chen, C.-Y., 1991, Identification of multiple nuclear factors that interact with cyclic adenosine 3′ 5′-monophosphate response element-binding protein and activating transcription factor-2 by protein-protein interactions. Mol. Endocrinol. 5: 256.PubMedCrossRefGoogle Scholar
  22. Hurst, H.C., Totty, N.F., and Jones, N.C., 1991, Identification and functional characterization of the cellular activating transcription factor-43 (ATF-43) protein. Nucl. Acids Res. 19: 4601.PubMedCrossRefGoogle Scholar
  23. Ivashkiv, L.B., Liou, H.C., Kara, C.J., Lamph, W.W., Verma, I.M., and Glimcher, L.H., 1990, mXBP/CRE-BP2 and c-Jun form a complex which binds to the cAMP, but not to the 12-0-tetradecanoyl phorbol-13-acetate response element. Mol. Cell. Biol. 10: 1609.PubMedGoogle Scholar
  24. Landschulz, W.H., Johnson, P.F., and McKnight, S.L., 1988, The leucine zipper; a hypothetical structure common to a new class of DNA binding proteins. Science 240: 1759.PubMedCrossRefGoogle Scholar
  25. Lee, K.A.W., Fink, S J., Goodman, R.H., and Green, M.R., 1989, Distinguishable promoter elements are involved in transcriptional activation by E1A and cyclic AMP. Mol. Cell. Biol. 9: 4390.PubMedGoogle Scholar
  26. Lillie, J.W., and Green, M.R., 1989, Transcription activation by the adenovirus Ela protein. Nature 338: 39.PubMedCrossRefGoogle Scholar
  27. Liou, H.-C., Boothby, M.R., Finn, P.W., Davidon, R., Nabavi, N., Zeleznik-Le, N.J., Ting, J.P.-Y., and Glimcher, L.H., 1990, A new member of the leucine zipper class of proteins that binds to the HLA DRa promoter. Science 247: 1581.PubMedCrossRefGoogle Scholar
  28. Liu, F., and Green, M.R., 1990, A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus Ela protein. Cell 61: 1217.PubMedCrossRefGoogle Scholar
  29. Maekawa, T., Matsuda, S., Fujisawa, J.-I., Yoshida, M., and Ishii, S., 1991, Cyclic AMP response element-binding protein, CRE-BP1, mediates the ElA-induced but not the fax-induced trans-activation. Oncogene 6: 627.PubMedGoogle Scholar
  30. Maekawa, T., Sakura, H., Kanei-Ishii, C., Sudo, T., Yoshimura, T., Fujisawa, J., Yoshida, M., and Ishii, S., 1989, Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J. 8: 2023.PubMedGoogle Scholar
  31. Masquilier, D., and Sassone-Corsi, P., 1992, Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun. J. Biol. Chem. (in press).Google Scholar
  32. Merino, A., Buckbinder, L., Mermelstein, F.H., and Reinberg, D., 1989, Phosphorylation of cellular proteins regulates their binding to the cAMP-response element. J. Biol. Chem. 264: 21266.PubMedGoogle Scholar
  33. Nishizuka, Y., 1986, Studies and perspectives of protein kinase C. Science 233: 305.PubMedCrossRefGoogle Scholar
  34. Roesler, W.J., Vanderbark, G.R., and Hanson, R.W., 1988, Cyclic AMP and the induction of eukaryotic gene expression. J. Biol. Chem. 263: 9063.PubMedGoogle Scholar
  35. Sassone-Corsi, P., Visvader, J., Ferland, L., Mellon, P.L. and Verma, I.M., 1988, Induction of protooncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element. Genes & Dev. 2: 1529.CrossRefGoogle Scholar
  36. Sassone-Corsi, P., 1988, Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A-transactivation. Proc. Natl. Acad. Sci. USA 85: 7192.PubMedCrossRefGoogle Scholar
  37. Sassone-Corsi, P., Ransone, L.J., and Verma, I.M., 1990, Cross-talk in signal transduction: TPA-inducible factor Jun/AP-1 activates cAMP-responsive enhancer elements. Oncogene 5: 427.PubMedGoogle Scholar
  38. Shaw, G., and Kamen, R., 1986, A conserved AU sequence from the 31 untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659.PubMedCrossRefGoogle Scholar
  39. Yamamoto, K.K., Gonzales, G.A., Briggs, III W.H., and Montminy, M.R., 1988, Phosphorylation-induced binding and transcriptional efficiency of nuclear factor CREB. Nature 334: 494.PubMedCrossRefGoogle Scholar
  40. Yamamoto, K.K., Gonzales, G.A., Menzel, P., Rivier, J., and Montminy, M.R. 1990, Characterisation of a bipartite activator domain in transcription factor CREB. Cell 60: 611.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Denis Masquilier
    • 1
  • Brid M. Laoide
    • 1
  • Véronique Delmas
    • 1
  • Rolf P. de Groot
    • 1
  • Nicholas S. Foulkes
    • 1
  • Enrico Benusiglio
    • 1
  • Carlos A. Molina
    • 1
  • Florence Schlotter
    • 1
  • Paolo Sassone-Corsi
    • 1
  1. 1.Faculté de MédecineLaboratoire De Génétique Moléculaire des Eucaryotes, CNRS, U184 INSERM, Institut de Chimie BiologiqueStrasbourgFrance

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