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Reduced Virulence of S. Typhimurium with Mutations in Global Regulatory Genes

  • J. A. Harrison
  • D. Pickard
  • A. Khan
  • S. N. Chatfield
  • C. J. Dorman
  • G. Dougan
  • C. E. Hormaeche
Part of the NATO ASI Series book series (NSSA, volume 245)

Abstract

Some proteins which play a role in pathogenicity are expressed on the surface of the Salmonella cell or are located within the periplasm, e.g. flagella, exotoxins, fimbrial adhesins, haemolysins and outer membrane proteins.

Keywords

Outer Membrane Protein Glycine Betaine phoA Gene Great Relaxation Global Regulatory Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Manoil, C. and Beckwith, J., 1985, TnphoA: A transposon probe for protein export signals P.N.A.S. 82:8129.Google Scholar
  2. Miller, I., Maskell, D., Hormaeche, C.E., Johnson, K., Pickard, D. and Dougan, G., 1989, Isolation of orally attenuated Salmonella typhimurium following TnphoA mutagenesis. Infect. Immun. 57:2758.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. A. Harrison
    • 2
  • D. Pickard
    • 3
  • A. Khan
    • 2
  • S. N. Chatfield
    • 3
  • C. J. Dorman
    • 1
  • G. Dougan
    • 4
  • C. E. Hormaeche
    • 2
  1. 1.Department of Biochemistry, Medical Sciences InstituteUniversity of DundeeDundeeUK
  2. 2.Department of PathologyUniversity of CambridgeCambridgeUK
  3. 3.Medeva Group ResearchImperial CollegeLondonUK
  4. 4.Department of BiochemistryImperial CollegeLondonUK

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