Mucosal Immunity: The Role of Secretory Immunoglobulin a in Protection Against the Invasive Pathogen Salmonella typhimurium
Many pathogens gain entry into a host organism by crossing the epithelia of the digestive, respiratory or genital tracts. The main defense against this entry is the mucosal immune system. In the gut mucosa, antigen sampling sites contain organized mucosal lymphoid tissue including lymphoid follicles. These cellular assemblies, which form large aggregates in Peyer’s patches, sample lumenal antigens, resulting in the stimulation of both T cells and B lymphoblasts, committed to IgA synthesis. This leads to the production of secretory antibodies of the IgA isotype. Secretory IgA (slgA) antibodies are thought to act by immune exclusion. That is, slgA prevents the pathogen from contacting the mucosal surface by agglutination, entrapment of immune complexes in the mucus, and clearance by peristalsis (Brandtzaeg, 1989; Childers, et al., 1989; Mestecky, 1988).
KeywordsInsertion Mutation Oral Challenge Mucosal Immune Response Mucosal Lymphoid Tissue Sal4 Antigen
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