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Experimental Salmonella typhimurium — Induced Gastroenteritis

  • Chapter
Biology of Salmonella

Part of the book series: NATO ASI Series ((NSSA,volume 245))

Abstract

The rising incidence of salmonellosis in developed countries has refuelled intensive research into the pathogenesis of disease caused by Salmonella spp. These organisms cause two types of disease in man — acute gastroenteritis and systemic typhoid disease — as well as other important infections in domestic animals. It is highly desirable therefore, that we seek to understand the detailed biological and biochemical mechanisms involved in the pathogenesis of disease caused by these organisms. The gains from fundamental studies could be twofold. First, a greater ability to control infection caused by such a wide-spread pathogen whose eradication from the food chain would seem to be an impracticable aspiration. Second, one would hope that deeper insights into the fundamental mechanisms of disease causation would help generate greater confidence in the use of live metabolically crippled Salmonellae as Salmonella vaccines (O’Callaghan et al., 1988) or as vectors for delivering extraneous immunogens (Charles and Dougan, 1990).

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References

  • Candy, D. C. A. and Stephen, J., 1989, Salmonella, in: “Enteric Infecton. Mechanisms, Manifestations and Management”, Farthing M. J. G., Keusch G. T., (eds), Chapham and Hall Medical, London, p 289.

    Google Scholar 

  • Charles, I. and Dougan, G., 1990, Gene expression and the development of live enteric vaccines, TIBTECH., 8: 117.

    Article  CAS  Google Scholar 

  • Chopra, A. K., Houston, C. W., Peterson, J. W., Prasad, R. Mekalanos, J. J., 1987, Cloning and expression of the Salmonella enterotoxin gene, J. Bact., 169: 5095.

    PubMed  CAS  Google Scholar 

  • Chopra, A. K., Peterson, J.W., Houston, C. W., and Prasad, R., 1991, Enterotoxin-associated DNA sequence homology between Salmonellae species and Escherichia coli, FEMS (Fed Eur Microbiol Soc) Microbiol Lett, 77: 133.

    Article  CAS  Google Scholar 

  • Clarke, G. J., Qi, G.-M., Wallis, T. S., Starkey, W. G., Collins, J., Spencer, A. J., Haddon, S. J., Osborne, M. P., Worten, K. J., and Stephen, J., 1988, Expression of an antigen in strains of Salmonella typhimurium which reacts with antibodies to cholera toxin, J. Med. Microbiol., 25:139.

    Article  PubMed  CAS  Google Scholar 

  • Collins, J., Starkey, W. G., Wallis, T. S., Clarke, G. J., Worten, K. J., Spencer, A. J., Haddon, S. J., Osborne, M. P., Candy, D.C.A., and Stephen, J., (1988), Intestinal enzyme profiles in normal and rotavirus-infected mice, J. Pediatr. Gastroenterol. Nutr., 7: 264.

    Article  PubMed  CAS  Google Scholar 

  • Douce, G. R., Amin, I. I., and Stephen, J., 1991, Invasion of HEp-2 cells by strains of Salmonella typhimurium of different virulence in relation to gastroenteritis, J. Med. Microbiol. 35:349.

    Article  PubMed  CAS  Google Scholar 

  • Duebbert, I. E., and Peterson, J. W., 1985, Enterotoxin-induced fluid accumulation during experimental salmonellosis and cholera: involvement of prostaglandin synthesis by intestinal cells, Toxicon 23:157.

    Article  PubMed  CAS  Google Scholar 

  • Elsinghorst, E. A., Baron, L. S., Kopecko, D.J., 1989, Penetration of human intestinal epithelial cells by Salmonella: molecular cloning and expression of Salmonella typhi invasion determinants in Escherichia coli, Proc. Natl. Acad. Sci. USA, 86: 5173.

    Article  PubMed  CAS  Google Scholar 

  • Ernst, R. K., Dombroski, D. M., and Merrick, J. M., 1990, Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium, Infect. Immun. 58:2014.

    PubMed  CAS  Google Scholar 

  • Field, M., Smith, P. L., Bolton, J. E., 1980, Ion transport across the isolated intestinal mucosae of the winter flounder, Pseudopleuronectes americanus H; effects of cyclic AMP, J. Membrane Biol., 55: 157.

    Article  CAS  Google Scholar 

  • Fields, P. I., Groisman, E. A., and, Heffron, F., 1989, A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells, Science, 243: 1059.

    Article  PubMed  CAS  Google Scholar 

  • Fields, P. I, Swanson, R. V., Haidaris, C. G., and Heffron, F., 1986, Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent, Proc. Natl. Acad. Sci.,USA, 83: 5189.

    Article  PubMed  CAS  Google Scholar 

  • Finklestein, R. A., Marchlewicz, B. A., Mcdonald, R. J., Boesman-Finklestein, M., 1983, Isolation and characterizaton of a cholera-related enterotoxin from Salmonellae typhimurium, FEMS (Fed Eur Microbiol. Soc) Microbiol Lett, 17: 239.

    Article  Google Scholar 

  • Finlay, B. B., and Falkow, S., 1988, Comparison of the invasion strategies used by Salmonella choleraesuis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication, Biochimie, 70: 1089.

    Article  PubMed  CAS  Google Scholar 

  • Finlay, B. B., Gumbiner, B., and Falkow, S., 1988a, Penetration of Salmonella through a polarized Madin-Darby canine kidney epithelial cell monolayer, J. Cell Biol., 107:221.

    Article  PubMed  CAS  Google Scholar 

  • Finlay, B. B., Heffron, F., and Falkow, S., 1989, Epithelial cell surfaces induce Salmonella proteins required for bacterial adherence and invasion, Science, 243: 940.

    Article  PubMed  CAS  Google Scholar 

  • Finlay, B.B., Starnbach, M. N., Francis, C. L., Stocker, B. A. D., Chatfield, S., Dougan, G., and Falkow, S., 1988, Identification and characterization of TnphoA mutants of Salmonella that are unable to pass through a polarized MDCK epithelial cell layer, Mol. Microbiol., 2: 757.

    Article  PubMed  CAS  Google Scholar 

  • Gahring, L. C., Heffron, F., Finlay, B. B., and Falkow, S., 1990, Invasion and replication of Salmonella typhimurium in animal cells, Infect. Immun., 58:443.

    PubMed  CAS  Google Scholar 

  • Galan, J. E., and Curtiss III, R., 1989, Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells, Proc. Natl. Acad. Sci. USA, 86: 6383.

    Article  PubMed  CAS  Google Scholar 

  • Galan, J. E., and Curtiss III, R., 1990, Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling, Infect. Immun., 58: 1879.

    PubMed  CAS  Google Scholar 

  • Galan, J. E., and Curtiss III, R., 1991, Distribution of the invA,-B,-C, and -D genes of Salmonella typhimurium amoung Salmonella serovars: invA mutants of S. typhi are deficient for entry into mammalian cells. Infect Immun 59:2901.

    PubMed  CAS  Google Scholar 

  • Giannella, R. A., 1979, The importance of the intestinal inflammatory reaction in Salmonella-mediated intestinal secretion, Infect. Immun., 23: 140.

    PubMed  CAS  Google Scholar 

  • Giannella, R. A., Formal, S. B., Dammin, G. J., and Collins, H., 1973, Pathogenesis of Salmonellosis. Studies of fluid secretion, mucosal invasion and morphological reaction in the rabbit ileum, J. Clin. Invest. 52:441.

    Article  PubMed  CAS  Google Scholar 

  • Giannella, R. A., Gots, R. E., Charney, A. N., Greenough, W. B., and Formal, S. B., 1975, Pathogenesis of Salmonella mediatedintestinal fluid secretion, Gastroenterol, 69: 1238.

    CAS  Google Scholar 

  • Gots, R. E., Formal, S. B., Giannella, R. A., 1974, Indomethacin inhibition of Salmonella typhimurium, Shigella flexneri, and cholera-mediated rabbit ileal secretion, J. Inf. Dis., 130: 280.

    Article  CAS  Google Scholar 

  • Groisman, E. A., Chiao, E., Lipps, C. J., and Heffron, F., 1989, Salmonella typhimurium phoP virulence gene is a transcriptional regulator, Proc. Natl Acad. Sci. USA, 86: 7077.

    Article  PubMed  CAS  Google Scholar 

  • Groisman, E. A., and Saier, M. H., 1990, Salmonella virulence: new clues to intramacrophage survival, OBS, 15-January 1990, 30.

    Google Scholar 

  • Hallback, D. A., Hulten, L., Jodal, M., Lindhagen, J., and Lundgren, O., 1978, Evidence for the existence of a countercurrent exchanger in the small intestine of man. Gastroenterol. 74:683.

    CAS  Google Scholar 

  • Lee, C. A., and Falkow, S., 1990, The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proc. Natl Acad. Sci. USA 87:4304.

    Article  PubMed  CAS  Google Scholar 

  • Lee, C. A., Jones, B. D., and Falkow, S., 1992, Identification of a Salmonella typhimurium, invasion locus by selection for hyperinvasive mutants, Proc. Natl Acad. Sci. USA, 89: 1847.

    Article  PubMed  CAS  Google Scholar 

  • Lundgren, O., 1988, Factors controlling absorption and secretion in the small intestine, in: “Bacterial infections of respiratory and gastrointestinal mucosae”, W Donachie, E Griffiths, J Stephen, eds., special publication of the Society for General Microbiology, vol 24,, UK, IRL Press, Oxford, p 97.

    Google Scholar 

  • Miller, S. I., Kukral, A. M., and Mekalanos J. J., 1989, A two component regulatory system (phoP,phoQ) controls Salmonella typhimurium virulence, Proc. Natl. Acad. Sci. USA, 86: 5054.

    Article  PubMed  CAS  Google Scholar 

  • Miller I., Maskell, D., Hormaeche, C., Pickard, D., and Dougan, G., 1989, The isolation of orally attenuated Salmonella typhimurium following TnphoA mutagenesis, Infect. Immun., 57: 2758.

    PubMed  CAS  Google Scholar 

  • Miller, V.L., Taylor, R.K. and Mekalanos, J.J. (1987). Cholera toxin transcriptional activator ToxR is a transmembrane DNA membrane protein. Cell 48:271–279.

    Article  PubMed  Google Scholar 

  • O’Callaghan, D., Maskel, D., Liew, F., Easmon, C.S.F., and Dougan G., 1988, Characterisation of aromatic-and purine-dependent Salmonella typhimurium:attenuation, prsistance and ability to induce immunity in BALB/c mice. Infect. Immun. 56:419.

    PubMed  Google Scholar 

  • Osborne M P, Haddon S J, Worten K J, Spencer A J, Starkey W G, Thornber D, and Stephen J (1991a). A study of the microcirculation in whole villi of neonatal mice using a peroxidase histochemical staining method. J. Pediatr. Gastroenterol. Nutr. 12:105.

    Article  PubMed  CAS  Google Scholar 

  • Osborne M P, Haddon S J, Worten K J, Spencer A J, Starkey W G, Thornber D, and Stephen J (1991b). Rotavirus-induced changes in the microcirculation of intestinal villi of neonatal mice in relation to the induction and persistence of diarrhea. J. Pediatr. Gastroenterol. Nutr. 12:111.

    Article  PubMed  CAS  Google Scholar 

  • Prasad, R., Chopra, A.K., Peterson, J.W., Pericas, R. and Houston, C.W. (1990). Biological and immunological characterization of a cloned cholera toxin-like enterotoxin from Salmonella typhimurium. Microbial Pathogenesis 9:315.

    Article  PubMed  CAS  Google Scholar 

  • Qi, G.-M., Clarke, G. J., Wallis, T. S., and Stephen, J., 1989, The influence of cultural conditions on the expression in Salmonella typhimurium of an antigen related to cholera toxin, J. Med. Microbiol., 30: 213.

    Article  PubMed  CAS  Google Scholar 

  • Roggin, G. M., Banwell, J. G., Yardley J. H., and Hendrix T. R., 1972, Unimpaired response of rabbit jejunum to cholera toxin after selective damage to villus epithelium, Gastroenterology, 63: 981.

    PubMed  CAS  Google Scholar 

  • Salmon, S. E., 1980, Cancer Chemotherapy, in: “Review of medical pharmacology,” Meyers F.H., et al. eds. 7th edn. Lange Medical Publications, Los Altos, CA., p 477.

    Google Scholar 

  • Small P. L. C., Isberg, R. R., and Falkow, S., 1987, Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudotuberculosis, and Yersinia enterocolitica to enter and replicate within HEp-2 cells, Infect. Immun., 55: 1674.

    PubMed  CAS  Google Scholar 

  • Spencer, A. J., Osborne, M. P., Haddon, S. J., Collins, J., Starkey, W. G., Candy, D. C. A., and Stephen. J., 1990, X-ray microanalysis of rotavirus-infected mouse intestine: a new concept of diarrhoeal secretion, J Pediatr Gastroenterol Nutr. 10:516.

    Article  PubMed  CAS  Google Scholar 

  • Starkey W G, Candy D C A, Collins J, Spencer A J, Osborne M P and Stephen J (1990a). An invitro model to study aspects of the pathophysiology of murine rotavirus-induced diarrhoea. J.Pediatr. Gastroenterol. Nutr. 10, 361.

    Article  PubMed  CAS  Google Scholar 

  • Starkey W G, Candy D C A, Collins J, Spencer A J, Osborne M P and Stephen J (1990b). Transport of water and electrolytes by rotavirus-infected mouse intestine. A time course study. J. Pediatr. Gastroenterol. Nutr. 11, 254–260.

    Article  PubMed  CAS  Google Scholar 

  • Stephen, J., Osborne, M. P., 1988, Pathophysiological mechanisms in diarrhoeal disease, in: “Bacterial infections of respiratory and gastrointestinal mucosae”, W Donachie, E Griffiths, J Stephen, eds., special publication of the Society for General Microbiology, vol 24, UK, IRL Press, Oxford, p 149.

    Google Scholar 

  • Stephen, J., and Pietrowski, R. A., 1986, “Bacterial Toxins,” 2nd. edn. Van Nostrand Reinhold (UK) Co. Ltd., Wokingham, UK.

    Google Scholar 

  • Stephen, J., Wallis, T. S., Starkey, W. G., Candy, D.C.A., Osborne, M.P., and Haddon, S. J., 1985, Salmonellosis: in retrospect and prospect, in: “Microbial toxins and diarrhoeal disease,” eds. Evered, D., Whelan, J., Pitman, London (Ciba Foundation Symposium 112) p 175.

    Google Scholar 

  • Wallis, T. S., Hawker, R. J. H., Candy, D.C.A., Qi, G.-M., Clarke, G. J., Worten, K. J., Osborne M. P. and Stephen, J., 1989, Quantification of the leucocyte influx into rabbit ileal loops induced by strains of Salmonella typhimurium of different virulence, J. Med. Microbiol., 30: 149.

    Article  PubMed  CAS  Google Scholar 

  • Wallis, T. S., Starkey, W. G., Stephen. J., Haddon, S. J., Osborne, M. P., Candy, D. C. A., 1986a Enterotoxin production by Salmonella typhimurium strains of different virulence, J. Med. Microbiol., 21: 19.

    Article  PubMed  CAS  Google Scholar 

  • Wallis, T. S., Starkey, W. G., Stephen, J., Haddon, S. J., Osborne, M. P., Candy, D. C. A., 1986, The nature and role of mucosal damage in relation to Salmonella typhimurium-induced fluid secretion in the rabbit ileum, J. Med. Microbiol., 22: 39.

    Article  PubMed  CAS  Google Scholar 

  • Wallis, T. S., Vaughan, A. T. M., Clarke, G. J., Qi, G.-M., Worten, K. J., Candy, D.C.A., Osborne, M. P., and Stephen, J., 1990, The role of leucocytes in the induction of fluid secretion by Salmonella typhimurium, J. Med. Microbiol., 31: 27.

    Article  PubMed  CAS  Google Scholar 

  • Welsh, M. J., Smith, P. L., Fromm M., and Frizell, R. A., 1982, Crypts are the site of intestinal fluid and electrolyte secretion, Science, 218: 1219.

    Article  PubMed  CAS  Google Scholar 

  • Worten, K. J., Candy D. C. A., Wallis T.S., Clarke, G. J., Osborne, M. P., Haddon, S. J., and Stephen, J., 1989, Studies on early association of Salmonella typhimurium with intestinal mucosa in vivo and in vitro: relationship to virulence, J. Med. Microbiol., 29: 283.

    Article  Google Scholar 

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Authors and Affiliations

  1. Microbial Molecular Genetics and Cell Biology Group School of Biological Sciences, University of Birmingham, PO Box 363, Birmingham, B15 2TT, UK

    John Stephen, Iqbal I. Amin & Gillian R. Douce

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  1. John Stephen
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  2. Iqbal I. Amin
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  3. Gillian R. Douce
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Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Felipe Cabello

  2. Cambridge University, Cambridge, UK

    Carlos Hormaeche

  3. University of Messina, Messina, Italy

    Pasquale Mastroeni  & Letterio Bonina  & 

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© 1993 Springer Science+Business Media New York

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Stephen, J., Amin, I.I., Douce, G.R. (1993). Experimental Salmonella typhimurium — Induced Gastroenteritis. In: Cabello, F., Hormaeche, C., Mastroeni, P., Bonina, L. (eds) Biology of Salmonella . NATO ASI Series, vol 245. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2854-8_23

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  • DOI: https://doi.org/10.1007/978-1-4615-2854-8_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6236-4

  • Online ISBN: 978-1-4615-2854-8

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