Early Events in the Pathogenesis of Enteric Fever in Mice
Salmonella typhimurium is the best studied of the salmonella which cause mouse typhoid (enteric fever). The portal of entry of salmonella that cause enteric fevers in the mouse and in other species is normally oral. However, the organisms quickly enter the lymph and blood, and most of the organisms that survive blood clearance become lodged in the spleen and liver where they grow and cause disease (Carter and Collins, 1974; Carter and Collins, 1974). Although salmonella which cause enteric fevers have been described as facultative intracellular parasites that resides within macrophages, there is controversy over the major location of S. typhimurium multiplication in vivo (Benjamin, et al, 1990; Carroll et al, 1979; Dunlap et al, 1991; Guo et al, 1986; Schurr et al, 1989).
KeywordsSuperoxide Tuberculosis Adenosine Penicillin Bacillus
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