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Early Events in the Pathogenesis of Enteric Fever in Mice

  • David E. Briles
  • Nancy E. Dunlap
  • Edward Swords
  • William H. BenjaminJr.
Part of the NATO ASI Series book series (NSSA, volume 245)

Abstract

Salmonella typhimurium is the best studied of the salmonella which cause mouse typhoid (enteric fever). The portal of entry of salmonella that cause enteric fevers in the mouse and in other species is normally oral. However, the organisms quickly enter the lymph and blood, and most of the organisms that survive blood clearance become lodged in the spleen and liver where they grow and cause disease (Carter and Collins, 1974; Carter and Collins, 1974). Although salmonella which cause enteric fevers have been described as facultative intracellular parasites that resides within macrophages, there is controversy over the major location of S. typhimurium multiplication in vivo (Benjamin, et al, 1990; Carroll et al, 1979; Dunlap et al, 1991; Guo et al, 1986; Schurr et al, 1989).

Keywords

Visceral Leishmaniasis Post Infection Enteric Fever Blood Clearance Natural Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • David E. Briles
    • 1
    • 2
    • 3
  • Nancy E. Dunlap
    • 1
    • 4
  • Edward Swords
    • 1
  • William H. BenjaminJr.
    • 1
    • 5
  1. 1.Department of MicrobiologyThe University of Alabama at BirminghamBirmingham, AlabamaUK
  2. 2.Department of PediatricsThe University of Alabama at BirminghamBirmingham, AlabamaUK
  3. 3.Department of Comparative MedicineThe University of Alabama at BirminghamBirmingham, AlabamaUK
  4. 4.Department of MedicineThe University of Alabama at BirminghamBirmingham, AlabamaUK
  5. 5.Department of PathologyThe University of Alabama at BirminghamBirmingham, AlabamaUK

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