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Regulation of Gastrin Releasing Peptide Gene Expression

  • Chapter
Growth Factors, Peptides and Receptors

Abstract

Bombesin/gastrin releasing peptide (BN/GRP) is an autocrine growth factor for some small cell lung cancer (SCLC) cells1. The GRP gene, which contains 2 introns and is localized to human chromosome 18q, is expressed in some SCLC cell lines such as NCI-H345 and H2092-4. GRP, which is present at high concentrations in classic SCLC cells, is released when the cAMP is elevated5,6. GRP binds with high affinity to NCI-H345 cells and stimulates phosphatidylinositol turnover7,8 The inositol-1,4,5-trisphosphate released elevates cytosolic calcium and the diacylglycerol released activated protein kinase C9,10 Also, GRP or BN stimulate SCLC colony formation and xenograft formation in nude mice11,12. SCLC growth in vitro and in vivo is blocked by synthetic BN/GRP receptor antagonists13,14

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References

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences Washington, DC, 20037, USA

    Muriel Draoui & Terry W. Moody

  2. Laboratory of Neurochemistry National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda, MD, 20892, USA

    James Battey

  3. Biomarkers & Prevention Res, Branch Division of Cancer Prevention and Control National Cancer Institute Kensington, MD, 20895, USA

    Michael Birrer

Authors
  1. Muriel Draoui
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  2. James Battey
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  3. Michael Birrer
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  4. Terry W. Moody
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Editors and Affiliations

  1. The George Washington University Medical Center, Washington, DC, USA

    Terry W. Moody

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© 1993 Plenum Press, New York

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Draoui, M., Battey, J., Birrer, M., Moody, T.W. (1993). Regulation of Gastrin Releasing Peptide Gene Expression. In: Moody, T.W. (eds) Growth Factors, Peptides and Receptors. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2846-3_33

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  • DOI: https://doi.org/10.1007/978-1-4615-2846-3_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44484-5

  • Online ISBN: 978-1-4615-2846-3

  • eBook Packages: Springer Book Archive

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