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MDGF-1: A New Tyrosine Kinase-Associated Growth Factor

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Growth Factors, Peptides and Receptors

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Abstract

We have isolated and characterized an apparently new tyrosine kinase-associated growth factor from milk. The factor has been provisionally named mammary-derived growth factor-1 (MDGF-1). The polypeptide has been purified to homogeneity from milk as well as from human primary breast tumors; it appears to be identical from the two sources1. The biological characteristics of MDGF-1 are marked by differential effects upon cellular collagen synthesis and proliferation. Type I collagen synthesis in normal fibroblasts is stimulated by the factor in the absence growth stimulation. In contrast, type IV collagen synthesis of normal and malignant mammary epithelial cells is stimulated by the factor in the presence growth stimulation1,2. We propose that the factor may play a role in normal mammary growth and development and in the regulation of breast cancer by autocrine and paracrine mechanisms.

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References

  1. M. Bano.D.S. Salomon, and W.R. Kidwell, Purification of a mammary-derived growth factor from human milk and human mammary tumors, J. Biol. Chem. 260: 5745 (1985).

    PubMed  Google Scholar 

  2. M. Bano, W.R. Kidwell, M.E. Lippman, and R.B. Dickson, Characterization of mammary-derived growth factor 1 receptors and response in human mammary epithelial cell lines, J. Biol. Chem. 265: 1874 (1990).

    PubMed  CAS  Google Scholar 

  3. M. Bano, R. Lupu, W.R. Kidwell, M.E. Lippman, and R.B. Dickson, Production and characterization of mammary-derived growth factor 1 in mammary epithelial cell lines, Biochem. 31: 610 (1992).

    Article  CAS  Google Scholar 

  4. M. Bano, P. Worland, W.R. Kidwell, M.E. Lippman, and R.B. Dickson, Receptor induced phosphorylation by mammary-derived growth factor 1 in mammary epithelial cells, J. Biol. Chem. 267: 10389 (1992).

    PubMed  CAS  Google Scholar 

  5. R.J. Grand, J.B. Watkins, and F.M. Tord, Development of the human gatrointestinal tract. A review, Gastroenterology 70: 790 (1976).

    PubMed  CAS  Google Scholar 

  6. V.S. Packard, “Human milk and infant formula”, Academic Press, New York (1982)

    Google Scholar 

  7. H. Beerens, C. Romond, and C. Neut, Influence of breast-feeding on the bifid flora of the newborn intestine, Am. J. Clin. Num. 33: 2434 (1980).

    CAS  Google Scholar 

  8. M. Klagsbrun, Bovine colostrum supports the serum-free proliferation of epithelial cells but not of fibroblasts in long-term culture, J. Cell Biol. 84: 808 (1980).

    Article  PubMed  CAS  Google Scholar 

  9. S.K. Sinha and A.A. Yunis, Isolation of colony stimulating factor from human milk, Biochem. Biophys. Res. Commun. 114: 797 (1983).

    CAS  Google Scholar 

  10. Y.W. Shing and M. Klagsbrun, Human and bovine milk contain different sets of growth factors, Endocrinol. 115: 273 (1984).

    Article  CAS  Google Scholar 

  11. J.A. Zwiebel, M. Bano, E. Nexo, D.S. Salomon, and W.R. Kidwell, Partial purification of transforming growth factors from human milk, Cancer Res. 46: 933 (1986).

    PubMed  CAS  Google Scholar 

  12. J.M. Connolly and D.P. Rose, Epidermal growth factor-like proteins in breast fluid and human milk, Life Science 42: 1751 (1988).

    Article  CAS  Google Scholar 

  13. J.C. Ness, L. Morgan, H.C. Outzen, and D. Tapper, Specific growth factor activity identifies and predicts murine mammary tumors, J. Surg. Res. 50:6 (1991).

    Article  PubMed  CAS  Google Scholar 

  14. D.J. Dunnington, R.G. Scott, M.A. Anzano, and R. Greig, Characterization and partial purification of human epithelial transforming factor, J. Cell. Biochem. 44: 229 (1990).

    Article  PubMed  CAS  Google Scholar 

  15. D.S. Licia, G. Merlo, F. Ciardiello, N. Kim, G.H. Smith, R.H. Callahan, and D.S. Salomon, Transforming growth factor a messenger RNA localization in the developing adult rat and human mammary gland by in situ hybridization, Develop. Biol. 140: 123 (1990).

    Google Scholar 

  16. S.M. Snedeker, C.F. Brown, and R.P. DiAugustine, Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse gland ductal morphogenesis, Proc. Natl. Acad. Sci. (USA) 88: 276 (1991).

    Article  CAS  Google Scholar 

  17. A. Grueters, J. Lakshmanan, R. Tarns, J. Alm, and D.A. Fisher, Nerve growth factor in mouse milk during early lactation: lack of dependency on submandibular salivary glands, Pediatr. Res. 19: 934 (1985).

    CAS  Google Scholar 

  18. R.B. Dickson and M.E. Lippman, Growth regulation of the normal and malignant breast epithelium, in The Breast Bland K. I. and Copeland E.M. (eds.), W.B. Saunders Co. 363 (1990).

    Google Scholar 

  19. S.E. Bates, N.E. Davidson, E. Valverius, C. Freter, R.B. Dickson, J.D. Tam, J.E. Kudlow, M.E. Lippman, and D.S. Salomon, Expression of transforming growth factor a and its mRNA in human breast cancer: its regulation and its possible functional significance, Mol. Endocrinol. 2: 543 (1988).

    CAS  Google Scholar 

  20. D. Yee, N. Rosen, R.E. Favoni, and K.J. Cullen, The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer, Cancer Treat. Res. 53: 93 (1991).

    CAS  Google Scholar 

  21. S.E. Bates, M.E. McManaway, M.E. Lippman, and R.B. Dickson, Characterization of estrogen responsive transforming activity in human breast cancer cell lines, Cancer Res. 46: 1707 (1986).

    PubMed  Google Scholar 

  22. K.K. Huff, D. Kaufman, K.H. Gabbay, E.M. Spencer, M.E. Lippman, and R.B. Dickson, Human breast cancer cells secrete an insulin-like growth factor-I related polypeptide, Cancer Res. 46: 4613 (1986).

    PubMed  CAS  Google Scholar 

  23. J.R.C. Sainsbury, A.J. Malcolm, D.R. Appleton, J.R. Farndon, and A.L. Harris, Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer, J. Clin. Pathol. 38:1225 (1985).

    Article  PubMed  CAS  Google Scholar 

  24. R.W. Furlanetto and J.N. DiCarlo, Somatomedin-C receptors and growth effects in human breast cells maintained in long-term tissue culture, Cancer Res. 44:2122 (1984).

    PubMed  CAS  Google Scholar 

  25. S.E. Bates, E.M. Valverius, B.W. Ennis, D.A. Bronzert, J.P. Sheridan, M.R. Stampfer, J.S. Mendelsohn, M.E. Lippman, and R.B. Dickson, Expression of the transforming growth factor a/Epidermal growth factor receptor pathway in normal human breast epithelial cells, Endocrinology 126: 596 (1990).

    Article  PubMed  CAS  Google Scholar 

  26. Q.T. Rohlik, D. Adams, F.C. Kull, and S. Jacobs, An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture, Biochem. Biophys. Res. Commun. 149: 276 (1991).

    Google Scholar 

  27. C. Knabbe, M.E. Lippman, L. Wakefield, K. Flauders, A. Kasid, R. Derynck, and R.B. Dickson, Evidence that TGF ß is a hormonally regulated negative growth factor in human breast cancer, Cell 48: 417 (1987).

    Article  PubMed  CAS  Google Scholar 

  28. G. Zugmaier, B.W. Ennis, B. Deschauer, D. Katz, C. Knabbe, G. Wilding, P. Daly, M.E. Lippman, and R.B. Dickson, Transforming growth factors type 131 and 132 are equipotent growth inhibitors of human breast cancer cell lines, J. Cell Physiol. 141: 353 (1989).

    Article  PubMed  CAS  Google Scholar 

  29. S.D. Hurd, M.D. Johnson, J.T. Forbes, T.L. Carty-Dugger, and C.L. Arteaga, Neutralizing TGF - 13 antibodies increase natural killer (NK) cell activity and inhibit human breast cancer cell tumorigenicity in athymic nude mice, Proceeding of the 1992 meeting of the American Association for Cancer Research (abstract).

    Google Scholar 

  30. G. Zugmaier, S. Paik, G. Wilding, C. Knabbe, M. Bano, R. Lupu, B. Deschauer, S. Simpson, R.B. Dickson, and M.E. Lippman, Transforming growth factor 131 induces cachexia and systemic fibrosis without an antitumor effect in nude mice, Cancer Res. 51: 3590 (1991).

    PubMed  CAS  Google Scholar 

  31. D.A. Bronzert, P. Pantazis, H.N. Antoniades, A. Kasid, N. Davidson, R.B. Dickson, and M.E. Lippman, Synthesis and secretion of PDGF-like growth factor by human breast cancer cell lines, Proc. Natl. Acad. Sci. U.S.A. 84:5763 (1987).

    Article  PubMed  CAS  Google Scholar 

  32. N. Weidner, J.P. Semple, W.R. Welch, and J. Folkman, Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma, N. Engl. J. Med. 324:1 (1991).

    Article  PubMed  CAS  Google Scholar 

  33. J. Folkman, What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst. 82:4 (1990).

    Article  PubMed  CAS  Google Scholar 

  34. C. Theillet, X.L. Roy, O.D. Lapeyriere, J. Grosgeorges, J. Adnane, S.D. Raynaud, J. Simony-Lafontaine, M. Goldfarb, C. Escot, D. Birnbaum, and P. Gaudray, Amplification of FGF-related genes in human tumors: possible involvement of HST in breast carcinomas, Oncogene 4: 915 (1989).

    PubMed  CAS  Google Scholar 

  35. S. Li and G.D. Shipley, Expression of multiple species of basic fibroblast growth factor mRNA and protein in normal and tumor-derived mammary epithelial cells in culture, Cell Growth and Diff. 2: 195 (1991).

    CAS  Google Scholar 

  36. M.S. Al-Adnani, J.A. Kirrane, and J.O. McGee, Inappropriate production of collagen and prolylhydroxylase by human breast cancer cells in vivo, Br. J. Cancer 31: 653 (1975).

    Article  PubMed  CAS  Google Scholar 

  37. S. Minafra, C. Luparello, F. Rallo, and I. Pucci-Minafra, Collagen biosynthesis by a breast carcinoma cell strain and biopsy fragments of the primary tumour, Cell Biol. Int. Rep. 12: 895 (1988).

    CAS  Google Scholar 

  38. D. Verhoeven, N. Bourgeois, A. Noel, J-M. Foidart, and N. Buyssens, The presence of a type IV collagen skeleton associated with periductal elastosis in breast cancer, J. Histochem. Cytochem. 38: 245 (1990).

    Article  PubMed  CAS  Google Scholar 

  39. M.S. Wicha, L.A. Liotta, B.K. Vonderhaar, and W.R. Kidwell, Effects of inhibition of basement membrane collagen deposition on rat mammary gland development, Develop. Biol. 80: 253 (1980).

    CAS  Google Scholar 

  40. L.A. Liotta, K. Tryggvason, S. Garbisa, I. Hart, C.M. Foltz, and S. Shafie, Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284: 67 (1980).

    Article  PubMed  CAS  Google Scholar 

  41. C. Charpin, L. Andrac, M. C. Habib, H. Vacheret, M.N. Lavaut, L. Xerri, D. Figarella-Branger, P. Casanova, and M. Toga, Correlation between laminin and type IV collagen distribution in breast carcinomas, and estrogen receptors expression, lymph node and vascular involvement, Med. Oncol. Tumor Pharmacother. 7: 43 (1990).

    PubMed  CAS  Google Scholar 

  42. M. Bano, M.B. Sabol, S. Paik, E. Barker, W.R. Kidwell, M.E. Lippman, and R.B. Dickson, Production and localization of mammary-derived growth factor 1 in human breast cancers, Proceeding of Am. Assoc. for Can. Res. 33: #470, 79 (1991).

    Google Scholar 

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Authors and Affiliations

  1. Gunma University School of Medicine, Maebashi, Gunma 371, Second Department of Surgery, Japan

    Junichi Kurebayashi

  2. Georgetown University, Lombardi Cancer Research Center, Washington, DC, 20007

    Junichi Kurebayashi, Mozeena Bano, Barbara Ziff, Michael D. Johnson, Francis G. Kern & Robert B. Dickson

  3. Cellco Advanced Bio-Reactors, Kensington, MD, 20895

    William R. Kidwell

Authors
  1. Junichi Kurebayashi
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  2. Mozeena Bano
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  3. Barbara Ziff
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  4. Michael D. Johnson
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  5. William R. Kidwell
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  6. Francis G. Kern
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  7. Robert B. Dickson
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  1. The George Washington University Medical Center, Washington, DC, USA

    Terry W. Moody

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© 1993 Plenum Press, New York

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Kurebayashi, J. et al. (1993). MDGF-1: A New Tyrosine Kinase-Associated Growth Factor. In: Moody, T.W. (eds) Growth Factors, Peptides and Receptors. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2846-3_29

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  • DOI: https://doi.org/10.1007/978-1-4615-2846-3_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44484-5

  • Online ISBN: 978-1-4615-2846-3

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