Estrogen Regulation of the Pituitary Insulin - Like Growth Factor System

  • Kathleen M. Michels
  • Wei-Hua Lee
  • Mark A. Bach
  • Alicia Seltzer
  • Juan M. Saavedra
  • Carolyn A. Bondy
Chapter
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)

Abstract

Insulin-like growth factor I (IGF-I) and the closely related IGF-II are homologous to proinsulin and share many of insulin’s effects on cell metabolism. In addition they stimulate cellular differentiation and proliferation1. Circulating IGF-I originating mainly from the liver, has classical endocrine actions2, however, local IGF-I production in many other tissues suggests an autocrine/paracrine role as we113. Most biological actions of the IGFs are mediated through the IGF-I receptor (IGFR-I) which has intrinsic tyrosine kinase activity4,5 Specific, high-affinity, insulin-like growth factor binding proteins (IGFBPs), present in the plasma and extracellular space, also bind the IGFs, modulating their interaction with the IGF-I receptor and perhaps targeting IGFs to specific loci6. To date, six different IGFBPs have been characterized7, among which IGFBP2 is particularly abundant in the pituitary8.

Keywords

Cholesterol Cellulose Ischemia Estrogen Tyrosine 

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Copyright information

© Plenum Press, New York 1993

Authors and Affiliations

  • Kathleen M. Michels
    • 1
  • Wei-Hua Lee
    • 2
  • Mark A. Bach
    • 2
  • Alicia Seltzer
    • 1
  • Juan M. Saavedra
    • 1
  • Carolyn A. Bondy
    • 2
  1. 1.Laboratory of Clinical ScienceSection on PharmacologyNimhUSA
  2. 2.Developmental Endocrinology BranchNational Institute of Child Health and Human DevelopmentBethesdaUSA

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