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Estrogen Regulation of the Pituitary Insulin - Like Growth Factor System

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Growth Factors, Peptides and Receptors

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Abstract

Insulin-like growth factor I (IGF-I) and the closely related IGF-II are homologous to proinsulin and share many of insulin’s effects on cell metabolism. In addition they stimulate cellular differentiation and proliferation1. Circulating IGF-I originating mainly from the liver, has classical endocrine actions2, however, local IGF-I production in many other tissues suggests an autocrine/paracrine role as we113. Most biological actions of the IGFs are mediated through the IGF-I receptor (IGFR-I) which has intrinsic tyrosine kinase activity4,5 Specific, high-affinity, insulin-like growth factor binding proteins (IGFBPs), present in the plasma and extracellular space, also bind the IGFs, modulating their interaction with the IGF-I receptor and perhaps targeting IGFs to specific loci6. To date, six different IGFBPs have been characterized7, among which IGFBP2 is particularly abundant in the pituitary8.

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Author information

Authors and Affiliations

  1. Laboratory of Clinical Science, Section on Pharmacology, Nimh, USA

    Kathleen M. Michels, Alicia Seltzer & Juan M. Saavedra

  2. Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD, 20892, USA

    Wei-Hua Lee, Mark A. Bach & Carolyn A. Bondy

Authors
  1. Kathleen M. Michels
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  2. Wei-Hua Lee
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  3. Mark A. Bach
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  4. Alicia Seltzer
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  5. Juan M. Saavedra
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  6. Carolyn A. Bondy
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Editor information

Editors and Affiliations

  1. The George Washington University Medical Center, Washington, DC, USA

    Terry W. Moody

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© 1993 Plenum Press, New York

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Michels, K.M., Lee, WH., Bach, M.A., Seltzer, A., Saavedra, J.M., Bondy, C.A. (1993). Estrogen Regulation of the Pituitary Insulin - Like Growth Factor System. In: Moody, T.W. (eds) Growth Factors, Peptides and Receptors. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2846-3_26

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  • DOI: https://doi.org/10.1007/978-1-4615-2846-3_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44484-5

  • Online ISBN: 978-1-4615-2846-3

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