Estrogen Regulation of the Pituitary Insulin - Like Growth Factor System

  • Kathleen M. Michels
  • Wei-Hua Lee
  • Mark A. Bach
  • Alicia Seltzer
  • Juan M. Saavedra
  • Carolyn A. Bondy
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


Insulin-like growth factor I (IGF-I) and the closely related IGF-II are homologous to proinsulin and share many of insulin’s effects on cell metabolism. In addition they stimulate cellular differentiation and proliferation1. Circulating IGF-I originating mainly from the liver, has classical endocrine actions2, however, local IGF-I production in many other tissues suggests an autocrine/paracrine role as we113. Most biological actions of the IGFs are mediated through the IGF-I receptor (IGFR-I) which has intrinsic tyrosine kinase activity4,5 Specific, high-affinity, insulin-like growth factor binding proteins (IGFBPs), present in the plasma and extracellular space, also bind the IGFs, modulating their interaction with the IGF-I receptor and perhaps targeting IGFs to specific loci6. To date, six different IGFBPs have been characterized7, among which IGFBP2 is particularly abundant in the pituitary8.


Estrous Cycle Anterior Pituitary 
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Copyright information

© Plenum Press, New York 1993

Authors and Affiliations

  • Kathleen M. Michels
    • 1
  • Wei-Hua Lee
    • 2
  • Mark A. Bach
    • 2
  • Alicia Seltzer
    • 1
  • Juan M. Saavedra
    • 1
  • Carolyn A. Bondy
    • 2
  1. 1.Laboratory of Clinical ScienceSection on PharmacologyNimhUSA
  2. 2.Developmental Endocrinology BranchNational Institute of Child Health and Human DevelopmentBethesdaUSA

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