Abstract
Since its initial isolation in 1973 and characterization as an inhibitor of pituitary growth hormone (GH) secretion, the observed biological actions of the tetradecapeptide, somatostatin (SRIF-14) have rapidly proliferated.to include a number of non-pituitary activities such as inhibition gastrointestinal endocrine and exocrine secretion, gastrointestinal motility and blood flow, and central nervous system activity (Reichlin, 1983a, 1983b). Several recent lines of evidence also suggest that in addition to having an indirect, systemic effect on growth related process mediated by GH, SRIF-14 may have direct effects on cell proliferation in numerous types of neoplastic tissues (De Feudis and Moreau, 1986; Moreau and De Feudis, 1987 Lamberts et al., 1987 Lamberts, 1988; Parmer, 1989 Lamberts et al., 1991). For example, we initially reported that the in vivo growth of the rat prostate tumor, R-3327, and the in vitro proliferation and in vivo growth of the NCI-H69 human small cell lung carcinoma cell line (SCLC), were inhibited by the potent octapeptide analogue of SRIF-14, BIM-23014 (3-(2naphthyl)-D-Ala-cyclo[Cys-Try-D-Trp-Lys-Val-Cys]-Thr-NH2) (Murphy et al., 1987 Taylor et al., 1988a, 1988b). Further evaluation of this phenomenom showed that the in vivo growth of several other tumor lines and solid tumors (prostate, breast, hepatic, chondrosarcoma, neuroblastoma) was retarded by chronic BIM-23014 administration (Bogden et al., 1988 Bogden at al., 1990a, 1990b). In some cases, the termination of SRIF analogue treatment, resulted in tumor regrowth suggesting that the antitumor activity of SRIF peptides is oncostatic rather than oncolytic in nature.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bogden, A.E, Taylor, J.E., Moreau J-P, Coy, D.H., Moreau, S., and LePage, D.J., 1988, In vivo responsiveness of human and animal tumors to somatostatin (SRIF) analogue BIM-23014C (DC13–116), Proc. Am. Assoc. Cancer Res. Abst. #56.
Bogden, A.E. Taylor, J.E., Moreau, J.-P., and Coy, D.H., 1990a,. Treatment of R-3327 prostate tumors with a somatostatin analogue (Somatuline) as adjuvant therapy following surgical castration, Cancer Res. 50:2646.
Bogden, A.E., Taylor, J.E., Coy, D.H., Keyes, S.R., Prevost, G., Kim, S.H., and Moreau, J.-P., 1992, In vivo screening of agonist and antagonist analogues of bombesin/gastrin releasing peptide versus human lung tumor xenografts, Proc. Am. Assoc. Cancer Res., Abst. #415
Bogden, A.E., Taylor, J.E., Keyes, S.R., Kim, S.H., and Moreau, J.-P., 1991, Inhibition of intradermal melanomas by topical application of Somatuline, a somatostatin analogue (BIM-23014C), Proc. Am. Assoc. Cancer Res., Abst. #334.
Bogden, A.E., Taylor, J.E., Moreau, J.-P., Coy, D.H., and LePage, D.J., 1990b, Response of human lung tumor xenografts to treatment with a somatostatin analogue (Somatuline), Cancer Res. 50:4360.
Cardona, C., Rabbitts, P.H., Spindel, E.R., Ghatei, M.A., Bleehen, N.M., Bloom, S.R., Reeve, J.G., 1991, Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines, Cancer Res. 51:5205.
Carney, D.N., 1991, Lung cancer biology, Eur. J. Cancer 27:366.
Carney, D.N., 1992, Biology of small-cell lung cancer, Lancet 339:843.
Corjay, M.H., Dobrzanski, D.J., Way, J.M., Viallet, J., Shapira, H., Worland, P., Sausville, E.A., and Battey, J.M., 1991, Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells, J. Biol. Chem. 266:18771.
Cuttitta, F., Carney, D.N., Mulshine, J., Moody, T.W., Fedorko, J., Fischler, A., and Minna, J.D., 1985, Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer, Nature 316:823.
Davis, T.P., Crowell, S., Taylor, J.E., Coy, D.H., Staley, J., and Moody, T.W., 1992, Metabolic stability and tumor inhibition of bombesin/GRP antagonists, Peptides 13:401.
DeFeudis, F.V., and Moreau, J.-P., 1986, Studies on somatostatin analogues might lead to new therapies for certain types of cancer, TiPS 7:384.
Lamberts, S.W.J., Koper, J.W., and Reubi, J.-C., 1987, Potential role of somatostatin analogues in the treatment of cancer, Eur. J. Clin. Invest. 17:281.
Lamberts, S.W.J., Krenning, E.P., and Reubi, J.-C., 1991, The role of somatostatin and its analogs in the diagnosis and treatment of tumors, Endocrine Rev. 12:450.
Mahmoud, S. Staley, J. Taylor, J.E., Bodgen, A.E., Moreau, J.-P., Coy, D.H., Avis, I., Cuttitta, F., Mulshine, J.L., and Moody, T.W., 1991, (psi13,14)Bombesin analogs inhibit the growth of small cell lung cancer in vitro and in vivo, Cancer Res. 51:1798.
Moody, T.W., Bertness, V., and Carney, D.N., 1983, Bombesin-like peptides and receptors in human tumor cell lines, Peptides 4:683.
Moreau, J.P., and DeFeudis, F.V., 1987, Pharmacological studies of somatostatin and somatostatin analogues: therapeutic advances and perspectives, Life Sci. 40:419.
Murphy, W.A., Lance, V.A., Moreau, S., Moreau, J.-P., and Coy, D.H., 1987, Inhibition of rat prostate tumor growth by an octapeptide analog of somatostatin, Life Sci. 40: 2515.
Nelson, J., Cremin, M., and Murphy, R.F., 1989, Synthesis of somatostatin by breast cancer cells and their inhibition by exogenous somatostatin and sandostatin, Br. J. Cancer 59:739.
Papotti, M., Macri, L., Bussolati, G., and Reubi J.-C., 1989, Correlative study of neuroendocrine differentiation and presence of somatostatin receptors in breast carcinomas, Int. J. Cancer 43:365.
Parmer, H., Bodgen, A., Mollard, M., de Rouge, B., Phillips, R.H., and Lightman, S.L., 1989, Somatostatin and somatostatin analogues in oncology, Cancer Treat. Rev. 16: 95
Reichlin, S., 1983a, Somatostatin, N. Eng. J. Med. 309:1495.
Reichlin, S., 1983b, Somatostatin, N. Eng. J. Med. 309:1556.
Setyono-Han, B., Henkelman, M.S., Foekens. J.A., and Klijn, J.G.M., 1987, Direct inhibitory effects of somatostatin (analogues) on the growth of human breast cancer cells, Cancer Res. 47:1566.
Siegel, R.A., Tolcsvai, L., and Rudin, M., 1988, Partial inhibition of the growth of transplanted Dunning rat prostate tumors with the long-acting somatostatin analogue Sandostatin (SMS 201–995), Cancer Res. 48:4651.
Staley, J., Coy, D.H., Taylor, J.E., Moreau, J.-P., and Moody, T.W., 1991, [DesMet14]bombesin analogues function as small cell lung cancer bombesin receptor antagonists, Peptides 12:145.
Taylor, J.E., Bogden, A.E., Moreau, J.-P., and Coy, D.H., 1988b, In vitro and in vivo inhibition of human small cell lung carcinoma (NCI-H69) growth by a somatostatin analogue. Biochem. Biophys. Res. Comm. 153:81.
Taylor, J.E., Coy, D.H., and Moreau, J.-P., 1988a, High affinity binding of [125I-Tyr11]somatostatin-14 to human small cell lung carcinoma (NCI-H69), Life Sci. 43: 421.
Thomas, F., Keyes, S., Taylor, J.E., Moreau, J.-P., and Bogden, A.E., 1991, In vivo inhibition of human small cell lung carcinoma (SCLC) NCI-H345 with BIM-26189 a bombesin (BN) antagonist, 6th Eur. Conf. Clinical Oncology & Cancer Nursing Abst. # 1112.
Weber, C., Merriam, L., Koschitzky, T., Karp, F., Benson, M., Forde, K., and LoGerfo, P., 1989, Inhibition of growth of human breast carcinomas in vivo by somatostatin analog SMS 201–995: Treatment of nude mouse xenografts, Surgery 106:416.
Woll, P.J., 1991a Neuropeptide growth factors and cancer, Br. J. Cancer 63:469.
Woll, P.J., 1991b, Growth factors and lung cancer, Thorax 46:924.
Yamada, Y., Post, S.R., Wang, K, Tager, H.S. Bell, G.I., and Seing, S., 1992, Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney, Proc. Natl. Acad. Sci. USA 89: 251.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Plenum Press, New York
About this chapter
Cite this chapter
Taylor, J.E. (1993). Identification and Characterization of Somatostatin (SRIF), Gastrin Releasing Peptide (GRP), and Neuromedin B (NMB) Receptors on Established Tumors and Tumor Cell Lines. In: Moody, T.W. (eds) Growth Factors, Peptides and Receptors. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2846-3_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2846-3_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-44484-5
Online ISBN: 978-1-4615-2846-3
eBook Packages: Springer Book Archive