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Structural Analysis of Ligand Binding Characteristics for the Bombesin/Gastrin-Releasing Peptide Receptor

  • David H. Coy
  • Robert T. Jensen
Chapter
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)

Abstract

Bombesin (Bn) 1 and its mammalian counterpart, gastrin-releasing peptide (GRP)2 have amino acid sequences which are closely related in their C-terminal regions (see Figure 1). They share a wide range of CNS and peripheral biological activities which have been recently reviewed3. Notable among them are increased grooming4, decreased food intakes5, and altered hormone secretion6 after central injection and stimulation of gastrin7 and gastric acid release8 and pancreatic amylase secretion9 after peripheral injection.

Keywords

Pancreatic Acinus Antagonist Structure Bombesin Receptor Bombesin Analogue Bombesin Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1993

Authors and Affiliations

  • David H. Coy
    • 1
  • Robert T. Jensen
    • 2
  1. 1.Peptide Research LaboratoriesTulane University Medical Center New OrleansUSA
  2. 2.Digestive Diseases BranchNational Institutes of Health BethesdaUSA

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