Structural Analysis of Ligand Binding Characteristics for the Bombesin/Gastrin-Releasing Peptide Receptor

  • David H. Coy
  • Robert T. Jensen
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


Bombesin (Bn) 1 and its mammalian counterpart, gastrin-releasing peptide (GRP)2 have amino acid sequences which are closely related in their C-terminal regions (see Figure 1). They share a wide range of CNS and peripheral biological activities which have been recently reviewed3. Notable among them are increased grooming4, decreased food intakes5, and altered hormone secretion6 after central injection and stimulation of gastrin7 and gastric acid release8 and pancreatic amylase secretion9 after peripheral injection.


Pancreatic Acinus Antagonist Structure Bombesin Receptor Bombesin Analogue Bombesin Antagonist 
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Copyright information

© Plenum Press, New York 1993

Authors and Affiliations

  • David H. Coy
    • 1
  • Robert T. Jensen
    • 2
  1. 1.Peptide Research LaboratoriesTulane University Medical Center New OrleansUSA
  2. 2.Digestive Diseases BranchNational Institutes of Health BethesdaUSA

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