Skip to main content
SpringerLink
Log in

Penicillium Marneffei: Dimorphism and Treatment

  • Chapter
Dimorphic Fungi in Biology and Medicine

Abstract

Penicillium marneffei grows at 25 °C as a mould typical of the genus, but is atypical by its ability to convert to a parasitic, yeast-like phase of growth at 37 °C on the appropriate media in vitro or in infected animals and humans. Natural infections occur in bamboo rats and in humans living in or having travelled in Indonesia or Southest Asian countries. The fungus infects cells of the reticuloendothelial system and is most often found in patients with diseases or disorders involving cell mediated immunity (Hodgkin’s disease, tuberculosis, corticosteroid therapy, and more recently, AIDS). The first natural human infection was reported in 1973. The total number of reported cases rose from 18 through 1987 to 73 as of June 1992, with 71% involving AIDS patients. To investigate the role of T cells in limiting P. marneffei disease, a mouse model was developed. Mice were depleted of CD4+ T cells, CD8+ T cells, or both. The results show that CD4+ T cells and, to a lesser extent CD8+ T cells play a role in the protective host response against P. marneffei.Because of the enormous increase of HIV infection in the endemic area, P. marneffei has the potential to emerge as a major opportunistic pathogen in AIDS.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J.I. Pitt, The genus Penicillium and its teleomorphic states Eupenicillium andTalaromyces ,Academic Press, New York (1979).

    Google Scholar 

  2. M. Capponi, P. Sureau, G. Segretain, Pénicillose de Rhizomys sinensis, Bull. Soc. Pathol. Exot. 49: 418 (1956).

    CAS  Google Scholar 

  3. G. Segretain, Description d’une nouvelle espèce de penicillium: Penicillium marneffei n. sp., Bull. Soc. Mycol. Fr. 75: 412 (1959).

    Google Scholar 

  4. G. Segretain, Penicillium marneffei n. sp., agent d’une mycose du système reticuloendothèlial,Mycopathol. Mycol. Appl. 11: 327 (1959).

    Article  CAS  Google Scholar 

  5. A.F. Di Salvo, A.M. Fickling and L. Ajello, Infection caused by Penicillium marneffei: description of first natural infection in man, Am. J. Clin. Pathol. 60: 259 (1973).

    Google Scholar 

  6. P. Jayanetra, P. Nitiyanant, L. Ajello, A.A. Padhye, S. Lolekha, V. Atichartakarn, P. Vathesatogit,B. Sathaphatayavongs and R. Prajaktam, Penicilliosis in Thailand: report of five human cases, Am. J. Trop. Med. Hyg. 33: 637 (1984).

    PubMed  CAS  Google Scholar 

  7. Z. Deng and D.H. Connor, Progressive disseminated penicilliosis caused by Penicillium marneffei: report of eight cases and differentiation of the causative organism from Histoplasma capsulatum, Am. J. Clin. Pathol. 84: 323 (1985).

    PubMed  CAS  Google Scholar 

  8. X.G. Wei, L.T. Zhou, Q.S. Zhang, S.Y. Song and O.G. Nong, Report of the first case of penicilliosis marneffei in China, Natl. Med. J. China 65: 533 (1985).

    CAS  Google Scholar 

  9. W.C. Yuen, Y.F. Chan, S.L. Loke, W.H. Seto, G.P. Poon and K.K. Wong, Chronic lymphadenopathy caused by Penicillium marneffei: a condition mimiking tuberculous lymphadenopathy, Br. J. Surg. 73: 1007 (1986).

    Article  PubMed  CAS  Google Scholar 

  10. Z. Deng, J.L. Ribas, D.W. Gibson and D.H. Connor, Infection caused by Penicillium marneffei in China and Southeast Asia: review of eighteen published cases and report of four more Chinese cases, Rev. Infect. Dis. 10: 640 (1988).

    Article  PubMed  CAS  Google Scholar 

  11. T.E.A. Peto, R. Bull, P.R. Millard, D.W.R. Mackenzie, C.K. Campbell, M.E. Haines and R.G. Mitchell, Systemic mycosis due to Penicillium marneffei in a patient with antibody to human immunodeficiency virus, J. Infect. 16: 285 (1988).

    Article  PubMed  CAS  Google Scholar 

  12. T. Ancelle, J. Dupouy-Camet, F. Pujol, L. Ferradini et J. Lapierre, Un cas de pénicilliose disseminée à Penicillium marneffei chez un malade atteint de SIDA, Bull. Soc. Fr. Mycol. Méd. 17: 73 (1988).

    Google Scholar 

  13. D.N.C. Tsang, J.K.C. Chang, Y.T. Lau, W. Lim, C.H.Tse and N.K. Chang, Penicillium marneffei infection: an underdiagnosed disease?, Histopathology 13: 311 (1988).

    Article  PubMed  CAS  Google Scholar 

  14. M.K. Piehl, R.L. Kaplan and M.H. Haber: Disseminated peniciliosis in a patient with acquired immunodeficiency syndrome, Arch. Pathol. Lab. Med. 112: 1262 (1988).

    PubMed  CAS  Google Scholar 

  15. M. Coen, M.A. Viviani, G. Rizzardini, A.M. Tortorano, C. Bonaccorso and T. Quirino, Disseminated infection due to Penicillium marneffei in a HIV positive patient, 5th International Conference on AIDS, Montreal (Quebec) Canada June 4–9, (1989) Abstract M.B.P. 94.

    Google Scholar 

  16. B. Sathapatayavongs, S. Damrongkitchaiporn, P. Saengditha, S. Kiatboonsri and P. Jayanetra,Disseminated penicilliosis associated with HIV infection, J. Infect. 19: 84 (1989).

    Article  PubMed  CAS  Google Scholar 

  17. C.A. Romana, M. Stern, S. Chovin, E. Drouhet et J.F. Pays, Pénicilliose pulmonaire à Penicillium marneffei chez un patient atteint d’une syndrome immunodeficitaire acquis, Deuxième cas français, Bull. Soc. Fr. Mycol. Méd. 18: 311 (1989).

    Google Scholar 

  18. J.K.C. Chan, D.N.C. Tsang and D.K.K. Wong, Penicillium marneffei in bronchoalveolar lavage fluid, Ada Cytol. 33: 523 (1989).

    CAS  Google Scholar 

  19. I.L. Wang, H.P. Yeh, S.C. Chang and J.S. Chen, Penicilliosis caused by Penicillium marneffei, A case report, Derm. Sinica 7: 19 (1989).

    Google Scholar 

  20. Y.F. Chan and T.C. Chow, Ultrastructural observations on Penicillium marneffei in natural human infection, Ultrastruct. Pathol. 14: 439 (1990).

    Article  PubMed  CAS  Google Scholar 

  21. C.M.J. Hulshof, R.A.A. van Zanten, J.F. Sluiters, M.E. van der Ende, R.S. Samson, P.E.Zondervan and J.H.T. Wagenvoort, Penicillium marneffei infection in an AIDS patient, Eur. J. Clin. Microbiol. Infect. Dis. 9: 370 (1990).

    Article  PubMed  CAS  Google Scholar 

  22. S. Chienchanvit, P. Mahanupab, P. Hirunsri and N. Vanittanakom, Cutaneous manifestations of disseminated Penicillium marneffei mycosis in five HIV-infected patients, Mycoses 34: 245 (1991).

    Article  Google Scholar 

  23. I. Hilmarsdottir, A. Datry, J.L. Meynard, O. Rogeaux, C. Katlana, M. Chalot, G. Guermonprez, G. Brucker, M. Danis and M. Gentilini, Infection disseminée à Penicillium marneffei observée chez deux patients infectés par le VIH, Réunion de la Societé Française de Mycologie Medicale, Novembre 22–23, 1991, Abstract p. 62.

    Google Scholar 

  24. D.N.C. Tsang, P.C.K. Li, M.S. Tsui, Y.T. Lau, K.F. Ma and E.K. Yeoh, Penicillium marneffei: another pathogen to consider in patients infected with human immunodeficiency virus, Rev. Infect. Dis. 13: 76 (1991).

    Article  Google Scholar 

  25. A.S. Sekhon, J. Galbrait, B.W. Mielke, W.A. Black, A.K. Garg, G. Sheehan, L.Stein, J.D. Glezes and C. Wong, Esoteric mycoses: cerebral phaeohyphomycosis caused by Xylohypha bantiana and penicilliosis marneffei, XI Congress of the International Society for Human and Animal Mycology, Montreal (Quebec) Canada, June 24–28, 1991, Abstract S13.4, p. 36.

    Google Scholar 

  26. P. de Truchis, M.E. Bonioux, J. Roussi, F. Paraire, P. Nordmann et E. Dournon, Septicemie à Penicillium marneffei au cours du SIDA, Réunion interdisciplinaire de chimioantobioticothèrapie, Paris, Décember 5, 1991, Abstract 35/C4.

    Google Scholar 

  27. D.J. Manion, F. Auclair and R. Saginur, Penicillium marneffei mycosis: the first Canadian case report, 59th Conjoint Meeting on Infectious Diseases, Québec (Québec). Canada December 2–5, 1991, Abstract C–3.

    Google Scholar 

  28. I. Kok, H. Boot, P.G.J.M. Rietra and H.M. Weigel, Successful treatment of Penicülium marneffei infection, 3rd European Conference on Clinical Aspects and Treatment of HIV Infections, Paris March 12–13, 1992, Abstract P18O.

    Google Scholar 

  29. K. Supparatpinyo, S. Chiewchanvit, P. Hirunsri, C. Uthammachai, K.E. Nelson and T.Sirisanthana, Penicülium marneffei infection in patients infected with human immunodeficiency virus, Clin. Infect. Dis. 14: 871 (1992).

    Article  PubMed  CAS  Google Scholar 

  30. W.M.S. Tsui, K.F. Ma and D.N.C. Tsang, Disseminated Penicülium marneffei infection in HIV-infected subjects, Histopathology 20: 287 (1992).

    Article  PubMed  CAS  Google Scholar 

  31. F.C. Odds, T. Arai, A.F. Di Salvo, E.G.V. Evans, R.J. Hay, H.S. Randhawa, M.G. Rinaldi and T.J.Walsh, Nomenclature of fungal disease: a report and recomendations from a Sub-Committee of the International Society for Human and Animal Mycology (ISHAM), J. Med. Vet. Mycol. 30: 1 (1992).

    Article  PubMed  CAS  Google Scholar 

  32. G.R. Garrison and K.S. Boyd, Dimorphism of Penicülium marneffei as observed by electron microscopy, Can. J. Microbiol. 19: 1305 (1973).

    Article  PubMed  CAS  Google Scholar 

  33. M.A. Viviani, unpublished data.

    Google Scholar 

  34. J. Van Cutsem and F. Van Gerven, Activité antifongique in vitro de l’itraconazole sur les champignons filamenteux opportunistes, Traitement de la kératomycose et de la pénicilliose éxperimentales, J. Mycol. Méd. 118: 10 (1991).

    Google Scholar 

  35. J.O. Hill, M. Awwad and R.J. North, Elimination of CD4+ suppressor T cells from susceptible BALB/c mice releases CD8+ T lymphocytes to mediate protective immunity against Leishmania, J. Exp. Med. 169: 1819 (1989).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. D. M. Dixon

    Present address: Division of Microbiology and Infectious Diseases, NIH/NIAID, Bethesda, Maryland, 20892, USA

Authors and Affiliations

  1. Istituto di Igiene e Medicina Preventiva, Università degli Studi, Milano, 20122, Italy

    M. A. Viviani

  2. Trudeau Institute, Saranac Lake, New York, 12983, USA

    J. O. Hill

  3. Laboratories for Mycology, Wadsworth Center for Labs and Research, New York State Department of Health, Albany, NY, 12201-0509, USA

    D. M. Dixon

Authors
  1. M. A. Viviani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. O. Hill
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. M. Dixon
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Janssen Research Foundation, Beerse, Belgium

    Hugo Vanden Bossche  & Frank C. Odds  & 

  2. University of Cambridge, Cambridge, UK

    David Kerridge

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Viviani, M.A., Hill, J.O., Dixon, D.M. (1993). Penicillium Marneffei: Dimorphism and Treatment. In: Vanden Bossche, H., Odds, F.C., Kerridge, D. (eds) Dimorphic Fungi in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2834-0_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2834-0_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6226-5

  • Online ISBN: 978-1-4615-2834-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation