Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules

  • Garth L. Nicolson
  • Timothy J. Yeatman
  • Robert J. Tressler
  • Timothy V. Updyke
  • Jun-ichi Hamada
  • Phillip G. Cavanaugh
Chapter
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 4)

Abstract

The metastatic spread of blood borne tumor cells to near and distant sites does not occur randomly. Certain tumors tend to metastasize to particular organ sites, and this process appears to be due to differnces in tumor cell and host organ molecular properties (Nicolson, 1988a; Nicolson, 1991; Zetter, 1990). Once in the blood, tumor types cells can circulate to virtually every organ, yet metastases of many common tumor types form only at certain sites (Sugerbaker, 1983). This brief review will consider some of the properties of tumor cells and some of the properties of host organ cells and stroma in the organ preference of metastasis. For addidtional information, the reader is refered to more extensive reviews (Nicolson, 1988a; Nicolson, 1989; Nicolson, 1991; Liotta et al., 1991b).

Keywords

Migration Lymphoma Electrophoresis Fractionation Oncol 

Abbreviations

HSE

Hepatic Sinusoidal Endothelial Cell;

HX

High;

LDGF-1

Lung-derived Growth Factor-1;

LX

Low;

P

Parental Cell Line;

Tf

Transferrin Family of Growth Factors

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Copyright information

© Plenum Press, New York 1993

Authors and Affiliations

  • Garth L. Nicolson
    • 1
  • Timothy J. Yeatman
    • 1
  • Robert J. Tressler
    • 1
  • Timothy V. Updyke
    • 1
  • Jun-ichi Hamada
    • 1
  • Phillip G. Cavanaugh
    • 1
  1. 1.Department of Tumor BiologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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