Summary
Endothelial cells express a variety of adhesive receptors that regulate their adhesion to extracellular matrix and the organization of cell-cell junctions. Most of the endothelial cell receptors for matrix proteins belong to the inteh=grin superfamily. Endothelial cells, as many other cell types, have many different integrin on their surface. This indicates that the interaction with matrix protiens is a complex phenomenon that requires multiple recognition mechanisms. We have only a very limited knowledge of the molecules present at endothelial cell-cell junctions. Integrins have been found to be localized in these structures. This suggests that they can play a role also in this homoytpic type of cell inteaction. Other molecules, however, structurally and fuctionally distinct from integrins (including cadherins and immunoglobulins) have been found in endothelial junctions. The reciprocal role of these proteins remains tobe fully defined.
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Abbreviations
- TNF :
-
Tumor Necrosis Factor;
- γIFN :
-
γ-interferon;
- PECAM :
-
Platelet Endothelial Cell Adhesion Molecule;
- Vn :
-
Vitronectin;
- Fg :
-
Fibrinogen;
- vWf :
-
vonWillebrand factor;
- Fn :
-
Fibronectin;
- Lm :
-
Laminin;
- Tsp :
-
Thrombospondin;
- Thr :
-
Thrombin;
- Coll :
-
Collagen
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© 1993 Plenum Press, New York
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Lampugnani, M.G., Resnati, M., Raiteri, M., Pittiglio, M., Ruco, L., Dejana, E. (1993). Adhesion Molecules at Endothelial Cell to Cell Junctions. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_10
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DOI: https://doi.org/10.1007/978-1-4615-2830-2_10
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