Abstract
The discovery of the clinical usefulness of 2′-deoxy- and 2′,3′-dideoxy nucleoside analogues for the treatment of viral infections such as acquired immunodeficiency syndrome, hepatitis B virus, cytomegalovirus and herpes simplex, and for the treatment of cancer has lead to the development of synthetic methodologies for the total synthesis of these types of agents. The advantage of a total synthetic approach is the ability to synthesize nucleoside analogues in which the base or the sugar portion of the molecule is not of a natural type. It also circumvents the use of naturally occurring nucleosides as starting material, which, in some cases are not readily available in large quantities and /or are of high cost.
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Beach, J.W., Jeong, L.S., Kim, H.O., Nampalli, S., Shanmuganathan, K., Chu, C.K. (1993). Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides. In: Chu, C.K., Baker, D.C. (eds) Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2824-1_12
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DOI: https://doi.org/10.1007/978-1-4615-2824-1_12
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