Sensitivity in the Response of Piriform Pyramidal cells to Fluctuations in Synaptic Timing

  • Alex Protopapas
  • James Bower


Current source density analysis has revealed a stereotyped pattern of synaptic input in the pyramidal cells of the piriform cortex in rat and opossum which is believed to underlie activity in the awake behaving animals as well. A realistic simulation of a piriform pyramidal cell was constructed in order to examine how fluctuations in synaptic timing affect cell response. Results indicate that cell response is considerably resilient to fluctuations in synaptic timing near physiological values.


Arrival Time Pyramidal Cell Synaptic Input Strong Shock Excitatory Input 
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  1. [1]
    Rodriguez, R. and Haberly, L. B. J. Neurophisiol., 61(4): 702–718, 1989.Google Scholar
  2. [2]
    Ketchum, K. L. and Haberly, L. B. J. Neurophysiol., 69(1): 248–260,1993.Google Scholar
  3. [3]
    Ketchum, K. L. and Haberly, L. B. J. Neurosa., 13(9): 3980–3985, 1993.Google Scholar
  4. [4]
    Wilson, M. A., Bhalla, U. S., Uhley, J. D., and Bower, J. M., in Advances in Neural Information Processing Systems, Morgan Kaufman, 485–492, 1989Google Scholar
  5. [5]
    Constanti, A. and Sim, J. A. J. Physiol., 387: 173–194, 1987.Google Scholar
  6. [6]
    Constanti, A., Galvan, M., Franz, P., and Sim, J. A. Pflügers Arch., 404: 259–265, 1985.CrossRefGoogle Scholar
  7. [7]
    Brown, D. A., Gähwiler, Griffith, W. H., and Halliwell, J. V. in Progress in Brain Research Vol. 83, Elsevier Science Publishers, New York, 1990.Google Scholar
  8. [8]
    Shepherd, G. M. The Synaptic Organization of the Brain, Oxford University Press, New York, 1990.Google Scholar
  9. [9]
    Wilson, M. A. An Analysis of Olfactory Cortical Behavior and Function Using Computer Simulation Techniques, CIT Thesis, 1991.Google Scholar
  10. [10]
    Haberly, L. B. and Bower, J. M. J. Neurophysiol., 51(1): 90–112, 1984.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Alex Protopapas
    • 1
  • James Bower
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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