Enterocin 1146, A Bacteriocin Produced by Enterococcus Faecium DPC1146

  • Colin Hill


It has long been known that the enterococci are capable of producing bacteriocins, some of which display a broad inhibitory spectrum (Brock et al., 1963). Recent reports also suggest that the ability of enterococci to inhibit Listeria monocytogenes may be relatively widespread (McKay, 1990; Arihara et al., 1991). However, these are preliminary studies and the bacteriocins involved have not been purified or characterized beyond their inhibitory activity against Listeria. Among the better-characterized enterococcal bacteriocins are enterocin E1A and E1B, produced by Enterococcus faecium E1 (Kramer & Brandis, 1975a). Enterocin E1A is a compound of low molecular mass (about 10 kDa), which is sensitive to proteases and is thermostable. It shows activity against other enterococcal strains and Listeria monocytogenes. The mode of action appears to be rapid, within 2–3 min, and bactericidal (Kramer & Brandis, 1975b). No significant lysis of sensitive strains was observed, but a rapid efflux of accumulated isoleucine was observed. These effects have been ascribed to the collapse of the membrane potential in other bacteriocin-strain interactions (Van Belkum et al., 1991). Enterocin E1B is a compound of large molecular mass (> 1000 kDa) which is thermolabile and trypsin resistant. However, no bacteriophage-like particles could be detected in enterocin E1B preparations.


Lactic Acid Bacterium Listeria Monocytogenes Enterococcus Faecium Bacteriocin Production Cheddar Cheese 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Colin Hill
    • 1
  1. 1.Department of Food MicrobiologyUniversity College CorkIreland

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