Genetics of drug resistance

  • June L. Biedler
  • Barbara A. Spengler
Part of the Cancer Treatment and Research book series (CTAR, volume 73)


Drug resistance is an ever present, dark shadow of cancer chemotherapy. Resistance developing as a consequence of treatment with cancer chemotherapeutic agents was a phenomenon recognized at the outset. In the days when the genome was generally considered to be static or fixed, tumor-cell drug resistance occurring in the patient, in animal models, and in cells in vitro was generally attributed to mutation. The advent of recombinant DNA technology as applied to mammalian cells, the recognition of the dynamic flexibility of the genome as in gene amplification, and the growing body of knowledge of the complexity and multiplicity of pathways governing cellular response have now provided other possible explanations for resistance development in addition to genotypic alteration.


Gene Amplification MDR1 Gene Chinese Hamster Cell DHFR Gene Drug Resistance Development 
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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • June L. Biedler
  • Barbara A. Spengler

There are no affiliations available

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