The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction

  • R. Khokha
  • P. Waterhouse


Tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors of the multi member family of matrix metalloproteinases (MMPs). Since MMP function is fundamental to events that require tissue remodelling, TIMPs regulate normal biological processes by inhibiting MMPs, and are of importance in pathological conditions. In this chapter we review evidence for the suppressive role of TIMP-1 in the malignant progression of cancer and of its regulatory function in controlling invasion during blastocyst implantation and development.

Key words

TIMP-1 metalloproteinases metastasis angiogenesis implantation 


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Copyright information

© Springer Science+Business Media Dordrecht 1994

Authors and Affiliations

  • R. Khokha
    • 1
  • P. Waterhouse
    • 2
  1. 1.Department of OncologyUniversity of Western Ontario, London Regional Cancer CentreLondonCanada
  2. 2.Amgen Institute, Ontario Cancer Institute, Departments of Immunology and Medical BiophysicsUniversity of TorontoTorontoCanada

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