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Biochemical Markers of Coronary Recanalization After Fibrinolytic Therapy

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The Modern Era of Coronary Thrombolysis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 160))

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Abstract

Rapid assessment of coronary patency in patients receiving intravenous fibrinolytic agents for the treatment of acute myocardial infarction is needed to identify those in whom adequate or sustained patency has not been achieved who could benefit from secondary mechanical interventions (e.g., coronary angioplasty and surgical revascularization). Because delayed initiation of secondary interventions will impede salvage of ischemic myocardium, markers chosen to assess the success of fibrinolytic therapy should have qualities including: 1) sensitivity to coronary recanalization within minutes of its occurrence facilitating prospective diagnosis; 2) rapidity for virtual online acquisition of results; and 3) specificity for persistent and complete recanalization, because those patients exhibiting transitory or incomplete recanalization may benefit from additional interventions as much as those with persistent arterial occlusion. Among these qualities, high specificity for arteries potentially in need of additional intervention is the most important, even if a modest number of patients with patent vessels are falsely identified as having an occluded artery.

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Authors and Affiliations

  1. Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, USA

    Dana R. Abendschein Ph.D (Research Associate Professor)

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  1. Dana R. Abendschein Ph.D
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Editors and Affiliations

  1. Thrombosis Research Center, University of Massachusetts Medical Center, Worcester, Massachusetts, USA

    Richard C. Becker M.D.

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Abendschein, D.R. (1994). Biochemical Markers of Coronary Recanalization After Fibrinolytic Therapy. In: Becker, R.C. (eds) The Modern Era of Coronary Thrombolysis. Developments in Cardiovascular Medicine, vol 160. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2618-6_16

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  • DOI: https://doi.org/10.1007/978-1-4615-2618-6_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6122-0

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