Radionuclide Imaging Techniques in the Thrombolytic Era

  • Diwakar Jain
  • Frans J. Th. Wackers
  • Barry L. Zaret
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 160)


Radionuclide imaging techniques have played an important role in the evaluation of left ventricular function, severity and extent of ischemia, viability and necrosis in patients with acute myocardial infarction. The information derived has formed a basis for risk stratification and selection of optimal treatment strategies for postinfarction patients in the prethrombolytic era. Reperfusion has altered the natural history of acute myocardial infarction. Effective early and sustained restoration of perfusion to acutely ischemic myocardium is the single most important factor in preserving myocardial function and reducing mortality and chronic disability. Current management strategies in acute myocardial infarction involve early diagnosis followed by prompt reperfusion, either pharmacologically or mechanically. Currently available thrombolytic agents achieve reperfusion in 75–80% of cases.1 When adequate reperfusion is not achieved with thrombolysis, immediate “salvage” angioplasty may be considered. Optimal utilization of reperfusion therapy would benefit from the availability of rapid non-invasive techniques for the early detection of reperfusion. Imaging may play a potential role in this as well as other areas in the diagnostic and therapeutic spectrum of reperfusion therapy in the modem era of coronary thrombolysis.


Left Ventricular Ejection Fraction Acute Myocardial Infarction Myocardial Perfusion Imaging Perfusion Imaging Left Ventricular Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Diwakar Jain
    • 1
  • Frans J. Th. Wackers
    • 1
  • Barry L. Zaret
    • 1
  1. 1.Yale University School of MedicineUSA

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