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Regulation of Ca2+ Channels in Vascular Smooth Muscle Cells by Cyclic Nucleotides and by G-Protein Gating

  • Nicholas Sperelakis
  • Zhiling Xiong
  • John Lorenz
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 159)

Abstract

In myocardial cells, cyclic AMP (cAMP) and cyclic GMP-dependent protein kinase (PK-A) stimulate slow Ca2+ channel activity, whereas cyclic GMP (cGMP) and cGMP-dependent protein kinase (cG-PK) inhibit channel activity (reviewed in 18). Phosphorylation by protein kinase C (PK-C) also stimulates activity of the myocardial slow Ca2+ channels (5). Intracellular ATP also modulates slow Ca2+ channel activity in myocardial cells, ATP being obligatory for channel activity (7, 14). Gating of myocardial Ca2+ slow channels by Gs-protein (GTP-activated alpha subunit) has also been demonstrated (19).

Keywords

Vascular Smooth Muscle Cell Cyclic Nucleotide A7r5 Cell Slow Channel Unfilled Circle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Nicholas Sperelakis
    • 1
  • Zhiling Xiong
    • 1
  • John Lorenz
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Cincinnati, College of MedicineCincinnatiUSA

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