Regulation of Ca2+ Channels in Vascular Smooth Muscle Cells by Cyclic Nucleotides and by G-Protein Gating

  • Nicholas Sperelakis
  • Zhiling Xiong
  • John Lorenz
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 159)


In myocardial cells, cyclic AMP (cAMP) and cyclic GMP-dependent protein kinase (PK-A) stimulate slow Ca2+ channel activity, whereas cyclic GMP (cGMP) and cGMP-dependent protein kinase (cG-PK) inhibit channel activity (reviewed in 18). Phosphorylation by protein kinase C (PK-C) also stimulates activity of the myocardial slow Ca2+ channels (5). Intracellular ATP also modulates slow Ca2+ channel activity in myocardial cells, ATP being obligatory for channel activity (7, 14). Gating of myocardial Ca2+ slow channels by Gs-protein (GTP-activated alpha subunit) has also been demonstrated (19).


Vascular Smooth Muscle Cell Cyclic Nucleotide A7r5 Cell Slow Channel Unfilled Circle 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Nicholas Sperelakis
    • 1
  • Zhiling Xiong
    • 1
  • John Lorenz
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Cincinnati, College of MedicineCincinnatiUSA

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