Hamster Cardiomyopathy: New Insights in the Pathogenesis of this Hereditary Disease

  • Gaétan Jasmin
  • Libuse Proschek
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 159)


Since 20 years ago, a new cardiomyopathic (CM) Syrian hamster colony, the UM-X7.1, has been established and raised under optimal environmental conditions (1). With a careful selection of breeders, it has been possible to preserve the original trait from the BIO 14.6 progenitors (2) and to arrive at a uniform and predictable expression of the disease. The average survival time of this new line is 250 days. Hence, it has been possible to carry out pathogenic studies in a reliable manner. Apart from a progressive blueing of the eyes due to venous congestion, the clinical pathological signs of this polymyopathy are very subtle. One may detect some impaired locomotor activity, becoming more evident with forced muscular exercise (3). Abnormal electrocardiogram patterns, as we will see in a moment, become significant after 150 days (4) when the heart tends to hypertrophy with concomitant dilatation of the right chambers and development of progressive changes of circulatory failure. Premature death may result from ventricular arrhythmia; otherwise, more than 50% of the remaining animals exhibit variable degree of cardiac failure. Signs of passive congestion are more obvious at autopsy when examining the lung or the liver. The hepatic tissue is often sclerotic with liquid effusion in the peritoneum and in the thoracic cavity, and ultimately one may observe a giant anasarca. By then, the entire myocardium becomes flabby due to dilatation of the heart cavities which often contain a mural thrombus (Fig. 1).


Mural Thrombus Optimal Environmental Condition Normal Hamster Passive Congestion Predictable Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jasmin G and Bajusz E (1973) Ann Anat Pathol 18:49–66Google Scholar
  2. 2.
    Bajusz E (1969) Am Heart J 77:689–696CrossRefGoogle Scholar
  3. 3.
    Homburger F, Nixon CW, Eppenberger M and Baker JR (1966) Ann NY Acad Sci 138:14–27PubMedCrossRefGoogle Scholar
  4. 4.
    Jasmin G, Proschek L, Vermeulen M, Li Fen and Cardinal R (in press) In: Negano M, Takeda N, Dhalla NS (eds) The Cardiomyopathic Heart. Raven Press, New YorkGoogle Scholar
  5. 5.
    Fitchett DH, Scott, J, Stephens HR and Peters TJ (1979) Cardiovasc Res 13:260–268PubMedCrossRefGoogle Scholar
  6. 6.
    Sole MJ, Lo CM, Laird CW, Sonnenblick EH and Wurtman RJ (1975) Circ Res 37:855–862PubMedCrossRefGoogle Scholar
  7. 7.
    Jasmin G and Proschek L (1982) In: Chazov E, Saks V and Rona G (eds) Advances in Myocardiology. Vol. 4, Plenum Press, New York pp.45–53Google Scholar
  8. 8.
    Jasmin G, Proschek L, Dechesne C and Léger J (1988) Proc Soc Exp Biol Med 188:142–148PubMedGoogle Scholar
  9. 9.
    Malhotra A, Karell M and Scheuer J (1985) J Mol Cell Cardiol 17:95–107PubMedCrossRefGoogle Scholar
  10. 10.
    Jasmin G, Solymoss CB and Proschek L (1979) Ann NY Acad Sci 317:338–348PubMedGoogle Scholar
  11. 11.
    Jasmin G and Proschek L (1980) In: Fleckenstein A and Roskamm H (eds) Calcium Antagonismus. Springer-Verlag Berlin, New York pp. 144–150CrossRefGoogle Scholar
  12. 12.
    Wikman-Coffelt, Sievers R, Parmley WW and Jasmin G (1986) Heart Circ Physiol H22–H28Google Scholar
  13. 13.
    Jasmin G and Proschek L (1989) In: Bender F, Meesmann (eds) Treatment with Gallopamil. Steinkopft Verlag, Darmstadt, pp. 13–23CrossRefGoogle Scholar
  14. 14.
    Dhalla NS, Singh A, Lee SL, Anand MB, Bernatsky AM and Jasmin G (1975) Clin Sci Mol Med 49:359–368PubMedGoogle Scholar
  15. 15.
    Slack BE, Boegman RJ, Downie JW and Jasmin G (1980) J Mol Cell Cardiol 12:179–185PubMedCrossRefGoogle Scholar
  16. 16.
    Harrow JAC, Singh N, Jasmin G and Dhalla NS (1975) Can J Biochem 53:1122–1127PubMedCrossRefGoogle Scholar
  17. 17.
    Wrogemann K and Nylen EG (1978) J Mol Cell Cardiol 10:185–195PubMedCrossRefGoogle Scholar
  18. 18.
    Jasmin G and Proschek C (1984) Can J Physiol Pharmacol 62:891–898PubMedCrossRefGoogle Scholar
  19. 19.
    Jasmin G and Preoschek L (1984) In: Sperelakis N, Caufield JB (eds) Calcium Antagonists, Mechanism of Action of Cardiac Muscle and Vascular Smooth Muscle. Martinus Nijhoff, Boston pp. 229–239Google Scholar
  20. 20.
    Jasmin G and Proschek L (1987) In: Kawai C and Abelmaun H (eds) Pathogenesis of Myocarditis and Cardiomyopathy. University of Tokyo Press, Tokyo pp. 79–89Google Scholar
  21. 21.
    Jasmin G, Proschek L, Brisson G and Dhalla NS (1987) In: Dhalla NS, Singal PK, Beamish RE (eds). Pathology of Heart Disease. Martinus Nijhoff, Boston, pp. 311–322CrossRefGoogle Scholar
  22. 22.
    Fabiato A (1983) Am J Physiol 245:C1–2/10PubMedGoogle Scholar
  23. 23.
    Proschek L and Jasmin G (1983) Muscle and Nerve 5:26–32CrossRefGoogle Scholar
  24. 24.
    Capasso JM, Sonnenblick EH and Anversa P (1990) Circ Res 67:1381–1393PubMedCrossRefGoogle Scholar
  25. 25.
    Makino N, Jasmin G, Beamish RE and Dhalla NS (1985) Biochem Biophys Res Commun 133:491–497PubMedCrossRefGoogle Scholar
  26. 26.
    Panagia V, Lee SL, Singh A, Pierce G, Jasmin G and Dhalla NS (1986) Can J Cardiol 2:236–247PubMedGoogle Scholar
  27. 27.
    Berry B, Poulsen R, Yunge L, Brunewald P, Fitchett D, de Chastonay C, Gabbiani G and Hüttner I (1983) J Mol Cell Cardiol 15:503–513PubMedCrossRefGoogle Scholar
  28. 28.
    Caufield JB (1966) Ann NY Acad Sci 138:151–152CrossRefGoogle Scholar
  29. 29.
    Roberds SL, Ervasti JM, Anderson, Ohlendieck K, Kahl SD, Zoloto D and Campbell KP (in press) J Biol ChemGoogle Scholar
  30. 30.
    Matsumura K, Tome FMS, Ollin H, Azibi K, Chaouch M, Kaplan JC, Fardeau M and Campbell KP (1992) Nature 359:320–322PubMedCrossRefGoogle Scholar
  31. 31.
    Lakshminarayanaiah N (1991) In: Hurwitz L, Partridge LD and Leach JK (eds) Calcium Channels: Their Properties, Functions, regulation and Clinical Relevance. CRC Press Inc. Boca Raton, Flo, USAGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Gaétan Jasmin
    • 1
  • Libuse Proschek
    • 1
  1. 1.University of MontrealMontrealCanada

Personalised recommendations