Abstract
Cutaneous melanoma is the most rapidly increasing malignant disease in the United States today. Currently, no effective therapeutic regimens are available, particularly after metastasis has occurred. Among solid tumors, however, malignant melanoma is considered one of the more suitable candidates for immunotherapy. One of our goals was to develop a metastatic human melanoma model in mice that mimics clinical disease and furthermore, to demonstrate that this model is useful for studying approaches to immunotherapy. We describe here the effects of antibody therapy in a model for metastasizing human melanoma, using monoclonal antibodies directed against the EGF-receptor.
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© 1994 Springer Science+Business Media New York
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Mueller, B.M., Reisfeld, R.A. (1994). Suppression of Human Melanoma Metastasis in SCID Mice with Antibodies to the EGF-Receptor. In: Valeriote, F.A., Corbett, T.H., Baker, L.H. (eds) Anticancer Drug Discovery and Development: Natural Products and New Molecular Models. Developments in Oncology, vol 74. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2610-0_7
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DOI: https://doi.org/10.1007/978-1-4615-2610-0_7
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