Marine Invertebrates and Microbes as Sources of Potential Antitumor Compounds
As part of the NCI’s broader goal of finding new leads to therapeutic agents in cancer chemotherapy, our National Cooperative Natural Product Drug Discovery Group (NCNPDDG) was organized to access a relatively understudied source of natural product leads: marine microbes and sessile marine organisms. We present here an overview of the structure of our group, a brief outline of our overall goals and strategy, and a summary of the advances we have made toward those goals.
KeywordsToxicity Leukemia Fractionation Tryptophan Microbe
Unable to display preview. Download preview PDF.
- 2.Long BH, Stringfellow DA: Inhibitors of topoisomerase II: Structure-activity relationships and mechanism of action of podophyllin congeners. In: Advances in Enzyme Regulation, G Weber (ed), Pergamon press, New York, 1988, Vol. 27, pp. 223–256.Google Scholar
- 4.Gerinn JH, Endicott JA, Juranka PF, et al: Homology between P-glycpprotein and a bacterial haemolysin transport protein suggests a model for multi-drug resistance. Nature 324:485–495, 1966.Google Scholar
- 5.Crosswell AR: Personal communication.Google Scholar
- 16.A considerably larger number of other samples have been submitted from the ongoing collection efforts at the academic laboratories, but this discussion will focus only on the samples collected in the Philippines.Google Scholar
- 26.Minale L, Riccio R, Sodano G: Avarol, a novel sesquiterpenoid hydroquinone with a rearranged drimane skeleton from the sponge Disidea avara. Tetrahedron Lett. 3401–3404, 1974.Google Scholar
- 38.Forenza S, Minale L, Riccio R, Fattorusso E: New bromo-pyrrole derivatives from the sponge Agelas oroides. J. Chem. Soc. Chem. Comm. 1129–1130, 1971.Google Scholar
- 39.Garcia EE, Benjamin LE, Fryer RI: Reinvestigation into the structure of oroidon, a bromopyrrole derivative from marine sponge. J. Chem. Soc. Chem. Comm. 78–79, 1973.Google Scholar