Preconditioning and the Coronary Vasculature
In 1986, Murry et al. showed that repeated short episodes of coronary occlusion protect the myocytes against subsequent sustained ischemia: This phenomenon was termed ischemic preconditioning . While there is no doubt that preconditioning limits infarct size, myocardial necrosis is not the only consequence of sustained/ischemia reperfusion: One or more hours of occlusion followed by reflow also results in ventricular arrhythmias, postischemic contractile dysfunction or “stunning,” and abnormalities in myocardial perfusion. The obvious question therefore arises: Do the benefits of ischemic preconditioning extend beyond the concept of myocyte viability and attenuate other deleterious sequelae associated with sustained ischemia/reperfusion?
KeywordsDepression Ischemia Covariance Superoxide Adenosine
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