Preconditioning and the Coronary Vasculature

  • Barbara Bauer
  • Robert A. Kloner
  • Karin Przyklenk
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 148)


In 1986, Murry et al. showed that repeated short episodes of coronary occlusion protect the myocytes against subsequent sustained ischemia: This phenomenon was termed ischemic preconditioning [1]. While there is no doubt that preconditioning limits infarct size, myocardial necrosis is not the only consequence of sustained/ischemia reperfusion: One or more hours of occlusion followed by reflow also results in ventricular arrhythmias, postischemic contractile dysfunction or “stunning,” and abnormalities in myocardial perfusion. The obvious question therefore arises: Do the benefits of ischemic preconditioning extend beyond the concept of myocyte viability and attenuate other deleterious sequelae associated with sustained ischemia/reperfusion?


Leave Anterior Descend Ischemic Precondition Coronary Blood Flow Coronary Occlusion Regional Myocardial Blood Flow 
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Copyright information

© Springer Science+Business Media Dordrecht 1994

Authors and Affiliations

  • Barbara Bauer
  • Robert A. Kloner
  • Karin Przyklenk

There are no affiliations available

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