Neoadjuvant chemotherapy in cervix cancer
Despite the decrease in the incidence of cervix cancer over the last decade, 13 500 new cases and 4400 deaths were expected in the United States in 1992 . Accessibility of the cervix for cytologic evaluation via the Pap smear, visual inspection by colposcopy, and histologic evaluation by biopsy have made cervical cacer a preventable and potentially curable disease. Identification and successful treatment of precursor lesions (cervical intraepithelial neoplasia) have accounted for the decreasing incidence. Cervix cancer is prevalent among women of low socioeconomic groups, high sexual promiscuity, and multiparity. It has been found to be associated with human papilloma virus infection; however, the precise role played by viral infection in cervix cancer remains to be defined. However, there is evidence accumulating linking HPV type 16, 18, 31, and 35 infections with lower-genital-tract cancers. This has led investigators to view cervical cancer as a sexually transmitted disease.
KeywordsCervical Cancer Cervix Cancer Induction Chemotherapy Cervical Intraepithelial Neoplasia Human Papilloma Virus Infection
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