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Molecular Aspects of the Control of Myocardial Relaxation

  • Ichiro Shiojima
  • Issei Komuro
  • Tsutomu Yamazaki
  • Ryozo Nagai
  • Yoshio Yazaki

Abstract

Hemodynamic overload induces left ventricular hypertrophy as a result of individual myocyte growth {1} and isozymic changes in the composition of contractile proteins {2,3}. However, myocytes form only one third of all cells in myocardium, and the remaining two thirds are nonmyocytes, including fibroblasts, vascular smooth muscle cells, and endothelial cells {1,4}. The remodeling of interstitial components, as well as that of myocytes, has been demonstrated to occur during the process of cardiac hypertrophy {5}.

Keywords

Sarcoplasmic Reticulum Cardiac Hypertrophy Pressure Overload Cardiac Fibroblast Myocardial Relaxation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Zak R (1973). Cell proliferation during cardiac growth. Am J Cardiol 31:211.PubMedCrossRefGoogle Scholar
  2. 2.
    Lompre AM, et al. (1979). Myosin isozyme redistribution in chronic heart overload. Nature 282:105.PubMedCrossRefGoogle Scholar
  3. 3.
    Izumo S, et al. (1987). Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. J Clin Invest 79:970.PubMedCrossRefGoogle Scholar
  4. 4.
    Frank JS, et al. (1974). The myocardial interstitium: Its structure and its role in ionic exchange. J Cell Biol 60:586.PubMedCrossRefGoogle Scholar
  5. 5.
    Weber KT, et al. (1988). Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res 62:757.PubMedCrossRefGoogle Scholar
  6. 6.
    Grossman W, et al. (1976). Diastolic properties of the left ventricle. Ann Intern Med 84:316.PubMedGoogle Scholar
  7. 7.
    Tada M, et al. (1978). Molecular mechanism of active transport by sarcoplasmic reticulum. Physiol Rev 58:1.PubMedGoogle Scholar
  8. 8.
    MacLennan D, et al. (1975). Calcium transport in sarcoplasmic reticulum. Annu Rev Biophys Bioeng 4:377.PubMedCrossRefGoogle Scholar
  9. 9.
    Suko J, et al. (1970). Intracellular calcium and myocardial contractility. III. Reduced calcium uptake and ATPase of sarcoplasmic reticulum fraction prepared from chronically failing calf hearts. Circ Res 27:235.PubMedCrossRefGoogle Scholar
  10. 10.
    Sordall LA, et al. (1973). Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am J Physiol 224:497.Google Scholar
  11. 11.
    Komuro I, et al. (1989). Molecular cloning and characterization of a Ca2 ++Mg2 +-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. J Clin Invest 83:1102.PubMedCrossRefGoogle Scholar
  12. 12.
    Nakanishi T, et al. (1984). Developmental changes in myocardial mechanical function and subcellular organelles. Am J Physiol 246:H615.PubMedGoogle Scholar
  13. 13.
    Ito Y, et al. (1974). Intracellular calcium and myocardial contractility. V. Calcium uptake of sarcoplasmic reticulum fractions in hypertrophied and failing rabbits hearts. J Mol Cell Cardiol 6:237.PubMedCrossRefGoogle Scholar
  14. 14.
    Tada M, et al. (1982). Phosphorylation of the sarcoplasmic reticulum and sarcolemma. Annu Rev Physiol 44:401.PubMedCrossRefGoogle Scholar
  15. 15.
    Nagai R, et al. (1989). Regulation of myocardial Ca2 +-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone. Proc Natl Acad Sci USA 86:2996.CrossRefGoogle Scholar
  16. 16.
    Caulfield JB, et al. (1979). The collagen network of the heart. Lab Invest 40:364.PubMedGoogle Scholar
  17. 17.
    Caspari PG, et al. (1977). Collagen in the normal and hypertrophied human ventricle. Cardiovas Res 11:554.CrossRefGoogle Scholar
  18. 18.
    Jalil JE, et al. (1989). Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res 64:1041.PubMedCrossRefGoogle Scholar
  19. 19.
    Ieki K, et al. (1989). Effect of long-term treatment with ß-blocker on cardiac hypertrophy in SHR. J Moll Cell Cardiol 21(Suppl V): 113.CrossRefGoogle Scholar
  20. 20.
    Medugorac I, et al. (1983). Characterization of left ventricular collagen in the rat. Cardiovasc Rex 17:15.CrossRefGoogle Scholar
  21. 21.
    Ignotz RA, et al. (1988). Transforming growth factor-ß stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261:4337.Google Scholar
  22. 22.
    Sporn MB, et al. (1987). Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol 105:1039.PubMedCrossRefGoogle Scholar
  23. 23.
    Kato H, et al. (1991). Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells. J Hyperten 9:17.Google Scholar
  24. 24.
    Dzau VJ. (1988). Tissue renin-angiotensin system: Physiologic and pharmacologic implications. Circulation 77(Suppl I):I1.PubMedGoogle Scholar
  25. 25.
    Eghbali M, et al. (1988). Collagen chain mRNAs in isolated heart cells from young and adult rats. J Mol Cell Cardiol 20:267.PubMedCrossRefGoogle Scholar
  26. 26.
    Khalil N, et al. (1989). Macrophage production of transforming growth factor ß and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med 170:727.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Ichiro Shiojima
  • Issei Komuro
  • Tsutomu Yamazaki
  • Ryozo Nagai
  • Yoshio Yazaki

There are no affiliations available

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