Molecular Aspects of the Control of Myocardial Relaxation

  • Ichiro Shiojima
  • Issei Komuro
  • Tsutomu Yamazaki
  • Ryozo Nagai
  • Yoshio Yazaki


Hemodynamic overload induces left ventricular hypertrophy as a result of individual myocyte growth {1} and isozymic changes in the composition of contractile proteins {2,3}. However, myocytes form only one third of all cells in myocardium, and the remaining two thirds are nonmyocytes, including fibroblasts, vascular smooth muscle cells, and endothelial cells {1,4}. The remodeling of interstitial components, as well as that of myocytes, has been demonstrated to occur during the process of cardiac hypertrophy {5}.


Sarcoplasmic Reticulum Cardiac Hypertrophy Pressure Overload Cardiac Fibroblast Myocardial Relaxation 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Ichiro Shiojima
  • Issei Komuro
  • Tsutomu Yamazaki
  • Ryozo Nagai
  • Yoshio Yazaki

There are no affiliations available

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