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Inosine 5’-Monophosphate Dehydrogenase as a Chemotherapeutic Target

  • Trevor J. Franklin
  • Gwynneth Edwards
  • Philip Hedge
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 370)

Abstract

Inosine 5’-monophosphate, EC 1.1.1.205 (IMPDH) catalyzes the conversion of IMP to XMP utilizing NAD as a proton acceptor. Its role in catalyzing the rate determining step in the biosynthesis of GTP1 gives IMPDH a position of central importance in cellular activity because of the myriad activities of GTP in biosynthesis and cellular regulation. The activity of IMPDH is much higher in proliferating tissues, both normal and malignant 2, 3 suggesting that the salvage of guanine by hypoxanthine-guanine phosphoribosyltransferase is probably inadequate to satisfy the requirements of dividing cells for guanine nucleotides.

Keywords

Mycophenolate Mofetil Guanine Nucleotide Respiratory Syncytial Virus Infection38 Phorbol Myristate Acetate Mycophenolic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Trevor J. Franklin
    • 1
  • Gwynneth Edwards
    • 2
  • Philip Hedge
    • 1
  1. 1.Cancer Research DepartmentZeneca PharmaceuticalsAlderley Park, MacclesfieldEngland
  2. 2.Department of Cell and Structural BiologyUniversity of ManchesterManchesterEngland

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