The Effect of Partial Hepatectomy on Blood Purine Levels in Rats and Patients
Purine metabolism is a key metabolic process after partial hepatectomy in the synthesis of DNA and RNA, and in the energy metabolism for hepatic regeneration1. However it is not evaluated in clinical situations due to the difficulty in measuring changes of purine levels in the liver itself. In order to get a basic understanding of purine metabolism in clinical hepatectomy cases, blood samples are used for analysis in this study. Also, the liver is the main nondietary source of purines in mammalian cells2 and changes in blood level may affect purine metabolism in various tissues.
KeywordsXanthine Oxidase Cirrhotic Patient Partial Hepatectomy Purine Nucleoside Purine Metabolism
Unable to display preview. Download preview PDF.
- 5.P. Kabasakalia, S. Kalliney, and A. Westcott, Enzymatic blood glucose determination by colorimetry of N, N-diethylailine-4-aminoantipyrine, Clin Chem. 20:606 (1974).Google Scholar
- 6.M. Usami, K. Furuchi, M. Ogino, J. Kotani, A. Iso, K. Oh, I. Yasuda, E. Sou, T. Kanamaru, H. Kasahara, Y. Saitoh, H. Yokoyama, and T. Yumisashi, Changes in purine and pyrimidine metabolism after partial hepatectomy in rats (in Japanese), Jap J Surg Metab Nutr. 27:35 (1993).Google Scholar
- 7.T. Kurokawa, T. Nonami, K. Kuroe, M. Satake, A. Harada, A. Nakano, and H. Takagi, Nucleotide metabolism in remnant rat liver after major hepatic resection (in Japanese), J Jap Surg Soc. 9:994 (1990).Google Scholar