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The Influence of Allopurinol on Renal Deterioration in Familial Nepropathy Associated with Hyperuricemia (FNAH)

  • María Eugenia Miranda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 370)

Abstract

The kidney has been traditionally considered as one of the two primary target organs in gout (1), but long-term follow-up studies have failed to show a deleterious effect of gout on renal function (2). FNAH is characterized by hyperuricemia or gout, usually appearing at an early age and often in both sexes, associated with progressive renal failure (3–17). The pathogenesis of this syndrome is controversial. Some authors believe that renal deterioration is the result of sustained hyperuricemia because in some patients allopurinol halted the progression of renal insufficiency (8, 16). Most authors, however, have documented the progression of renal disease despite allopurinol therapy (7, 10, 11, 14, 15, 17). We examined the influence of allopurinol on the evolution of renal disease in patients with FNAH.

Keywords

Uric Acid Progressive Renal Failure Baseline Serum Creatinine Uric Acid Crystal Serum Urate Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • María Eugenia Miranda
    • 1
  1. 1.Divisions of Internal Medicine, Clinical Biochemistry, Nephrology, Pediatrics, Radiology and Pathology“La Paz” Hospital, Universidad AutónomaMadridSpain

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