The Influence of Allopurinol on Renal Deterioration in Familial Nepropathy Associated with Hyperuricemia (FNAH)

  • María Eugenia Miranda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 370)


The kidney has been traditionally considered as one of the two primary target organs in gout (1), but long-term follow-up studies have failed to show a deleterious effect of gout on renal function (2). FNAH is characterized by hyperuricemia or gout, usually appearing at an early age and often in both sexes, associated with progressive renal failure (3–17). The pathogenesis of this syndrome is controversial. Some authors believe that renal deterioration is the result of sustained hyperuricemia because in some patients allopurinol halted the progression of renal insufficiency (8, 16). Most authors, however, have documented the progression of renal disease despite allopurinol therapy (7, 10, 11, 14, 15, 17). We examined the influence of allopurinol on the evolution of renal disease in patients with FNAH.


Uric Acid Progressive Renal Failure Baseline Serum Creatinine Uric Acid Crystal Serum Urate Concentration 
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  1. 1.
    Talbott JH, Terplan KL. The kidney in gout. Medicine (Balt) 1960; 39:405–407.Google Scholar
  2. 2.
    Berger L, Yü T-F. Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies. Am J Med 1975; 59:605–613.PubMedCrossRefGoogle Scholar
  3. 3.
    Duncan H, Dixon AS. Gout, familial hyperuricemia, and renal disease. Q J Med 1960; 29:127–135.PubMedGoogle Scholar
  4. 4.
    Rosenbloom FM, Kelley WN, Carr AA, Seegmiller JE. Familial nephropathy and gout in a kindred (abstract). Clin Res 1967; 15:270.Google Scholar
  5. 5.
    Treadwell BU. Juvenile gout. Ann Rheum Dis 1971; 30:279–284.PubMedCrossRefGoogle Scholar
  6. 6.
    Van Goor W, Kooiker CJ, Mees EJD. An unusual form of renal disease associated with gout and hypertension. J Clin Path 1971; 24:354–359.PubMedCrossRefGoogle Scholar
  7. 7.
    Massari PU, Hsu CH, Barnes RV, Fox IH, Gikas PW, Weller JM. Familial hyperuricemia and renal disease. Arch Intern Med 1980; 140:680–684.PubMedCrossRefGoogle Scholar
  8. 8.
    Simmonds HA, Warren DJ, Cameron JS, Potter CF, Farebrother DA. Familial gout and renal failure in young women. Clin Nephrol 1980; 14:176–182.PubMedGoogle Scholar
  9. 9.
    Farebrother DA, Pincott JR, Simmonds HA, Warren DJ, Dillon MJ, Cameron JS. Uric acid crystal-induced nephropathy: Evidence for a specific renal lesion in a gouty family. J Pathol 1981; 135:159–168.PubMedCrossRefGoogle Scholar
  10. 10.
    Richmond JM, Kincaid-Smith P, Whitworth JA, Becker GJ. Familial urate nephropathy. Clin Nephrol 1981; 16:163–168.PubMedGoogle Scholar
  11. 11.
    Leumann EP, Wegmann W. Familial nephropathy with hyperuricemia and gout. Nephron 1983; 34:51–57.PubMedCrossRefGoogle Scholar
  12. 12.
    Fleckenstein JL, Simkin PA. Corrected clearance identifies underexcretion of uric acid in a gouty kindred. Adv Exp Med Biol 1986; 195A:295–297.CrossRefGoogle Scholar
  13. 13.
    Calabrese G, Simmonds HA, Cameron JS, Davies PM. Precocious familial gout with reduced fractional urate clearance and normal purine enzymes. Q J Med 1990; 75:441–450.PubMedGoogle Scholar
  14. 14.
    Murakami T, Kawakami H, Nakatsuka K, Jojima K, Nohno H, Matsuzaki H. Underexcretory-type hyperuricemia, disproportionate to the reduced glomerular filtration rate in two boys with mild proteinuria. Nephron 1990; 56:439–442.PubMedCrossRefGoogle Scholar
  15. 15.
    Yokota N, Yamanaka H, Yamamoto Y, Fujimoto S, Eto T, Tanaka K. Autosomal dominant transmission of gouty arthritis with renal disease in a large Japanese family. Ann Rheum Dis 1991; 50:108–111.PubMedCrossRefGoogle Scholar
  16. 16.
    Moro F, Ogg C, Simmonds HA, et al. Familial juvenile gouty nephropathy with renal urate hypoexcretion preceding renal damage. Clin Nephrol. 1991;35:263–269.PubMedGoogle Scholar
  17. 17.
    Puig JG, Miranda ME, Mateos FA, Picazo ML, Jiménez ML, Calvin TS, Gil AA. Hereditary nephropathy associated with hyperuricemia and gout. Arch Intern Med 1993; 153: 357–365.PubMedCrossRefGoogle Scholar
  18. 18.
    Beck LH. Requiem for gouty nephropathy. Kidney Int 1986; 30:280–287.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • María Eugenia Miranda
    • 1
  1. 1.Divisions of Internal Medicine, Clinical Biochemistry, Nephrology, Pediatrics, Radiology and Pathology“La Paz” Hospital, Universidad AutónomaMadridSpain

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