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Nucleoside Diphosphate Kinase: an Old Enzyme with New Functions?

  • Michel Véron
  • Annemiek Tepper
  • Martin Hildebrandt
  • Ioan Lascu
  • Marie-Lise Lacombe
  • Joël Janin
  • Solange Moréra
  • Jaqueline Cherfils
  • Christian Dumas
  • Max Chiadmi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 370)

Abstract

This short review summarizes the recent work that we have performed on the biochemical and structural properties of nucleoside diphosphate (NDP) kinase.

Keywords

Adenylate Kinase Dictyostelium Discoideum Metastasis Suppressor Nucleoside Diphosphate Kinase Active Site Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Biggs, J., E. Hersperger, P. S. Steeg, L. A. Liotta and A. Shearn, 1990, A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell. 63: 933–940.PubMedCrossRefGoogle Scholar
  2. Cherfils, J., S. Moréra, I. Lascu, M. Véron and J. Janin, 1994, X-Ray structure of Nucleoside Diphosphate Kinase complexed with dTDP and Mg2+ at 2Å resolution. Biochemistry, in pressGoogle Scholar
  3. Chiadmi, M., S. Moréra, I. Lascu, C. Dumas, G. LeBras, M. Véron and J. Janin, 1993, The Awd Nucleoside Diphosphate Kinase, from Drosophila. Structure. 1: 283–293.PubMedCrossRefGoogle Scholar
  4. Dumas, C., I. Lascu, S. Morena, P. Glaser, R. Fourme, V. Wallet, M. Lacombe and M. J. Véron J., 1992, X-ray structure of Nucléoside diphiophate kinase. EMBO J. 11: 3203–3208.PubMedGoogle Scholar
  5. Gilles, A. M., E. Presecan, A. Vonica and I. Lascu, 1991, Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polipeptide chains responsible for heterogeneity of the hexameric enzyme. J. Biol. Chem. 266: 8784–8789.PubMedGoogle Scholar
  6. Hailat, N., D. R. Keim, R. F. Melhem, X. Zhu, C. Eckersckorn, G. M. Brodeur, C. P. Reynols, R. C. Seeger, F. Lottspeich, J. R. Strahler and S. M. Hanash, 1991, High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification. J. Clin. Invest. 88: 341–345.PubMedCrossRefGoogle Scholar
  7. Hildebrandt, M., M. Lacombe, S. Passeron and M. Veron, 1994, Human NDP-Kinase B binds specifically to single-stranded poly-pyrimidine DNA sequences, submitted.Google Scholar
  8. Keim, D., N. Hailat, R. Melhem, X. X. Zhu, I. Lascu, M. Veron, J. Strahler and S. M. Hanash, 1992, Proliferation related expression of P19/NM23 Nucleoside Diphosphate Kinase. J. Clinic. Invest. 89: 919–924.CrossRefGoogle Scholar
  9. Lacombe, M. L., V. Wallet, H. Troll and M. Veron, 1990, Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum. J Biol Chem. 265: 10012–8.PubMedGoogle Scholar
  10. Lacombe, M., X. Sastre-Gareau, I. Lascu, V. Wallet, J. Thiery and M. Veron, 1991, Overexpression of Nucleoside Diophosphate Kinase (Nm23) in Human Solid Tumors. Eur. J. Canc. 27: 1302–1307.CrossRefGoogle Scholar
  11. Lascu, I., A. Chaffotte, B. Limbourg-Bouchon and M. and Véron, 1992, A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation Killer of prune) affects stability but not catalytic efficiency of the enzyme. J. Biol. Chem. 267: 12775–12781.PubMedGoogle Scholar
  12. Lascu, I., D. Deville-Bonne, P. Glazer and M. Véron, 1993, Equilibrium dissociation and unfolding of nucleoside diphosphate kinase from Dictyostelium discoideum. Role of proline 100 in the stability of the hexameric enzyme. J. Biol. Chem. 268: 20268–20275.PubMedGoogle Scholar
  13. Leone, A., U. Flatow, C. Richterking, M. Sandeen, I. M. K. Margoulies, L. A. Liotta and P. S. Steeg, 1991, Reduced Tumor Incidence, Metastatic Potential, and Cytokine Responsiveness off Nm23 Transfected Melanoma Cells. Cell. 65: 25–35.PubMedCrossRefGoogle Scholar
  14. Munoz-Dorado, J., M. Inouye and S. Inouye, 1990, Nucleoside diphosphatase kinase from Myxococcus xanthus. I. Cloning and sequencing of the gene. J. Biol. Chem. 265: 2702–2706.PubMedGoogle Scholar
  15. Postel, E. H., S. J. Berberich, S. J. Flint and C. A. Ferrone, 1993, Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science. 261: 478–480.PubMedCrossRefGoogle Scholar
  16. Presecan, E., A. Vonica and I. Lascu, 1989, Nucleoside diphosphate kinase from human erythrocytes. Purification, molecular mass and subunit structure. FEBS lett. 250: 629–632.PubMedCrossRefGoogle Scholar
  17. Rosengard, A. M., H. C. Krutzsch, A. Shearn, J. R. Biggs, E. Barker, I. M. K. Margulies, C. R. King, L. A. Liotta and P. S. Steeg, 1989, Reduced Nm23/Awd protein in tumor metastasis and aberrant Drosophila development. Nature. 342: 177–180.PubMedCrossRefGoogle Scholar
  18. Sawan, A., I. Lascu, M. Veron, J. J. Anderson, C. Wright, C. H. W. Horne and B. Angus, 1994, NDP-K/nm23 Expression in Human Brest Cancer in Relation to relapse, Survival, and other Prognostic Factors: an Imuunohistochemical Study. J. Pathology. 172: 27–34.CrossRefGoogle Scholar
  19. Stahl, J. A., A. Lerone, A. M. Rosengard, L. Porter, C. R. King and P. S. Steeg, 1991, Identification of a second human nm23 gene, nm23-H2. Cancer Res. 51Google Scholar
  20. Steeg, P. S., G. Bevilacqua, L. Kopper, U. P. Thorgeirsson, J. E. Talmadge, L. A. Liotta and M. E. Sobel, 1988, Evidence for a novel gene associated with low tumor metastasic potential., J. Natn. Cancer Inst. 80: 200–204.CrossRefGoogle Scholar
  21. Wallet, V., R. Mutzel, H. Troll, O. Barzu, B. Wurster, M. Veron and M. L. Lacombe, 1990, Dictyostelium nucleoside diphosphate kinase highly homologous to Nm23 and Awd proteins involved in mammalian tumor metastasis and Drosophila development. J Natl Cancer Inst. 82: 1199–202.PubMedCrossRefGoogle Scholar
  22. Williams, R. L., D. A. Oren, J. Munoz-Dorado, S. Inouye, M. Inouye and E. Arnold, 1993, Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with nucleotide substrate at 2.0Å resolution. J. Mol. Biol 234: 1230–1247.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Michel Véron
    • 1
  • Annemiek Tepper
    • 1
  • Martin Hildebrandt
    • 1
  • Ioan Lascu
    • 1
  • Marie-Lise Lacombe
    • 2
  • Joël Janin
    • 3
  • Solange Moréra
    • 3
  • Jaqueline Cherfils
    • 3
  • Christian Dumas
    • 3
  • Max Chiadmi
    • 3
  1. 1.Unité de Biochimie CellulaireInstitut PasteurParisFrance
  2. 2.INSERM, U402Faculté Médecine St. AntoineParisFrance
  3. 3.Biologie StructuraleCNRSGif-sur-YvetteFrance

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