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Actin pp 85–96Cite as

Structural Requirements of Tropomyosin for Binding to Filamentous Actin

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 358))

Abstract

Tropomyosin is an actin binding protein found in virtually all eucaryotic cells. Since its early discovery (Bailey, 1948), the actin binding properties and regulatory functions of tropomyosin have been extensively investigated. In addition, tropomyosin has served as a prototype for the structure of α-helical coiled-coil proteins (Cohen and Parry, 1990). The recent recognition of the diversity of tropomyosins in different cell types and discovery of the relationship between cell shape and isoform expression are indicative of a fundamental role for tropomyosin in the actin cytoskeleton. There is a need for a better understanding of structure-function relationships in this protein.

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Author information

Authors and Affiliations

  1. Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA

    Sarah E. Hitchcock-DeGregori

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  1. Sarah E. Hitchcock-DeGregori
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Editors and Affiliations

  1. VA Medical Center, Albany, New York, USA

    James E. Estes

  2. Albany Medical College, Albany, New York, USA

    Paul J. Higgins

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© 1994 Springer Science+Business Media New York

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Hitchcock-DeGregori, S.E. (1994). Structural Requirements of Tropomyosin for Binding to Filamentous Actin. In: Estes, J.E., Higgins, P.J. (eds) Actin. Advances in Experimental Medicine and Biology, vol 358. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2578-3_8

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  • DOI: https://doi.org/10.1007/978-1-4615-2578-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6102-2

  • Online ISBN: 978-1-4615-2578-3

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