Calcium Homeostasis in Skeletal Muscle
Everybody has probably seen already too many lists of the multiple roles of changes in [Ca2+]int in the control of cell metabolism and in cell function. In fact, these lists have become so encompassing that I have now seen bold generalizations claiming that [Ca2+] increase is the common final pathway to effect metabolic change. It is not sure that this is the case, but the purpose here is to point out that Ca2+ is in fact a very dominant intracellular messenger. Just as an example, our laboratory has come across two roles of Ca2+ in E-C (excitation contraction) coupling that had not been described before (see following Chapter). Moreover, Ca2+ has what one might call structural roles, functions that it plays merely by being present, hence not requiring changes in [Ca2+]int or Ca-transients. These roles have to do with the stability of proteins and membranes, and with steady block of ion channels. In summary, Ca2+ has many known static and dynamic roles, and probably many more that are still ignored.
KeywordsDUCHENNE Muscular Dystrophy Image Energy Hydration Sphere Output Flux Dipole Energy
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