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Calcium Homeostasis in Skeletal Muscle

  • Eduardo Ríos
Chapter
Part of the NATO ASI Series book series (NSSA, volume 267)

Abstract

Everybody has probably seen already too many lists of the multiple roles of changes in [Ca2+]int in the control of cell metabolism and in cell function. In fact, these lists have become so encompassing that I have now seen bold generalizations claiming that [Ca2+] increase is the common final pathway to effect metabolic change. It is not sure that this is the case, but the purpose here is to point out that Ca2+ is in fact a very dominant intracellular messenger. Just as an example, our laboratory has come across two roles of Ca2+ in E-C (excitation contraction) coupling that had not been described before (see following Chapter). Moreover, Ca2+ has what one might call structural roles, functions that it plays merely by being present, hence not requiring changes in [Ca2+]int or Ca-transients. These roles have to do with the stability of proteins and membranes, and with steady block of ion channels. In summary, Ca2+ has many known static and dynamic roles, and probably many more that are still ignored.

Keywords

DUCHENNE Muscular Dystrophy Image Energy Hydration Sphere Output Flux Dipole Energy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1994

Authors and Affiliations

  • Eduardo Ríos
    • 1
  1. 1.Department of PhysiologyRush University School of MedicineChicagoUSA

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