Skip to main content

The Electrochemical Signal Transmission by the Acetylcholine Receptor: Single Channel Conductance Events and Oligochannels

  • Chapter
Book cover Bioelectrochemistry IV

Part of the book series: NATO ASI Series ((NSSA,volume 267))

  • 93 Accesses

Abstract

The rapid signal transmission between the nerves or a nerve and the target cells of a muscle or of a fish electric organ is mediated electrochemically. In cholinergic synapses (Fig.l) the electrochemical signal transfer, resulting in muscle contraction or in electric discharge, is initiated by nerve impulses triggering the release of the neurotransmitter acetylcholine [1,2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. B. Katz, The release of neural transmitter substances, Liverpool University Press, Liverpool (1969).

    Google Scholar 

  2. D. Nachmansohn, Harvey Lect., 49, 57 (1955).

    Google Scholar 

  3. J. P. Changeux, Trends Pharmacol. Sci, 11, 485 (1990).

    Article  CAS  Google Scholar 

  4. J. Cartaud, E. Benedetti, J.B. Cohen, J.C. Meunier and J.P. Changeux, Febs Lett., 33, 109 (1973).

    Article  CAS  Google Scholar 

  5. E. Nickel and L.T. Potter, Brain Research, 57, 508 (1973).

    Article  CAS  Google Scholar 

  6. H. W. Chang and E. Bock, Biochemistry, 18, 172 (1979).

    Article  CAS  Google Scholar 

  7. S.L. Hamilton, M. Mclaughlin and A. Karlin, Biochem. Biophys. Res. Commun., 79, 692 (1977).

    Article  CAS  Google Scholar 

  8. B.A. Suàrez-Isla and F. Hucho Fees Lett., 75, 69 (1977).

    Article  Google Scholar 

  9. J. Cartaud, J.L. Popot and J.P. Changeux, Febs Lett., 121, 327 (1980).

    Article  CAS  Google Scholar 

  10. R. Rüchel, D. Watters and A. Maelicke, Eur J. Biochem., 119, 215 (1981).

    Article  Google Scholar 

  11. M. Criado and F.J. Barrantes, Biochim. Biophys. Acta, 798, 374 (1984).

    CAS  Google Scholar 

  12. A. Aharanov, R. Tarrab-Hazdai, I. Silman and S. Fuchs, Lmmunochemistry, 14, 129 (1977).

    Article  Google Scholar 

  13. F. Spillecke, Thesis, University of Bielefeld (Germany), 395 (1983).

    Google Scholar 

  14. J.L. Popot, J. Cartaud and J.P. Changeux, Eur J. Biochem., 118, 203 (1981).

    Article  CAS  Google Scholar 

  15. H. Schindler, F. Spillecke and E. Neumann, Proc. Natl. Acad. Sci. Usa, 81, 6222 (1984).

    Article  CAS  Google Scholar 

  16. T. Schürholz, J. Weber and E. Neumann, Bioelectrochem. Bionerg., 21, 71 (1989).

    Article  Google Scholar 

  17. J. Lindstrom, J. Cooper and S. Tzartos, Biochemistry, 19, 1454 (1980).

    Article  CAS  Google Scholar 

  18. K. Imoto, C. Methfessel, B. Sakmann, M. Mishina, Y. Mori, T. Konno, K. Fukuda, M. Kurasaki, H. Bujo, Y. Fujita and S. Numa, Nature (London), 324, 670 (1986).

    Article  CAS  Google Scholar 

  19. J. W. Walker, R.J. Lukas and M.G. Mcnamee, Biochemistry, 20, 2191 (1981).

    Article  CAS  Google Scholar 

  20. J. K. Walker, C.A. Richardson and M.G. Mcnamee, Biochemistry, 23, 2329 (1984).

    Article  CAS  Google Scholar 

  21. T. Schürholz, J. Kehne, A. Gieselmann and E. Neumann, Biochemistry, 31, 5067 (1992).

    Article  Google Scholar 

  22. R. Anholt, J. Lindstrom and M. Montal, J. Biol. Chem., 256, 4377 (1981).

    CAS  Google Scholar 

  23. R. Anholt, D.R. Fredkin, T. Deerinck, M. Ellisman, M. Montal and J. Lindstrom, J. Biol. Chem., 257, 7122 (1982).

    CAS  Google Scholar 

  24. B.A. Suarez-Isla, K. Wan, J. Lindstrom and M. Montal, Biochemistry, 22, 2319 (1983).

    Article  CAS  Google Scholar 

  25. B. Sakmann, J. Patlak and E. Neher, Nature (London), 286, 71 (1980).

    Article  CAS  Google Scholar 

  26. B. Sakmann, C. Methfessel, M. Mishina, T. Takahashi, T. Takai, M. Kurasaki, K. Fukuda and S. Numa, Nature (London), 318, 538 (1985).

    Article  CAS  Google Scholar 

  27. J.-P. Changeux, A. Devillers-Thiéry and P. Chemoulli, Science, 225, 1335 (1984).

    Article  CAS  Google Scholar 

  28. H.W. Chang, E. Bock and E. Neumann, Biochemistry, 23, (1983).

    Google Scholar 

  29. E. Neumann, E. Boldt, B. Rauer and H. Wolf, Biocelectrochem. Bioenerg. 20, 45 (1988).

    Article  CAS  Google Scholar 

  30. M. Weber and J.-P. Changeux, Mol. Pharmacol., 10, 14546 (1984).

    Google Scholar 

  31. H. Sugiyama and J.-P. Changeux, Eur J. Biochemistry, 55, 505 (1975).

    Article  CAS  Google Scholar 

  32. G. Weiland, B. Georgia, S. Lgnappi, C.F. Chingell and P. Taylor, J. Biol. Chem., 252, 7648 (1977).

    CAS  Google Scholar 

  33. R.R. Neubig and J.B. Cohen, Biochemistry, 18, 5464 (1979).

    Article  CAS  Google Scholar 

  34. M. Schimerlik, U. Quast and M.A. Raftery, Biochemistry, 18, 1884 (1979).

    Article  CAS  Google Scholar 

  35. I. Silman and A. Karlin, Science, 164, 1420 (1969).

    Article  CAS  Google Scholar 

  36. R.N. Cox, M. Kawai, A. Karlin and P.W. Brandt, J. Membr. Biol., 51, 145 (1989).

    Google Scholar 

  37. H.A. Lester, M.E. Krouse, M.M. Nass, N.H. Wassermann and B.F. Erlanger, J. Gen. Physiol., 75, 193 (1984).

    Google Scholar 

  38. A. Maelicke, Angew. Chem., 96, 193 (1980).

    Article  Google Scholar 

  39. J.M. Wolosin, A. Lyddiatt, J.O. Dolly and E.A. Barnard, Eur. J. Biochem., 109, 495 (1980).

    Article  CAS  Google Scholar 

  40. J. Bernhardt and E. Neumann, in Neuroreceptors, F. Hucho (Editor) W. De Gruyter, Berlin, (1982) pp. 221–232.

    Google Scholar 

  41. J. Bernhardt and E. Neumann, Biophys. Chem., 15, 327 (1982).

    Article  CAS  Google Scholar 

  42. R.R. Neubig, N.D. Boyd and J.B. Cohen, Biochemistry, 21, 3460 (1982).

    Article  CAS  Google Scholar 

  43. P. Pennefather and D.M. Quastel, Br. J. Pharmacol., 77, (1982).

    Google Scholar 

  44. T. Heidmann, J. Bernhardt, E. Neumann and J. P. Changeux, Biochemistry, 22, 5452 (1983).

    Article  CAS  Google Scholar 

  45. G. Boheim. W. Hanke, F.J. Barrantes, H. Eibl, B. Sakmann, G. Fels and A. Maelicke, Proc. Natl. Acad. Sci. U.S.A., 78, 3586 (1981).

    Article  CAS  Google Scholar 

  46. M. Montal, P. Labarca, D.F. Fredkin, B.A. Suàrez-Isla and J. Lindstrom, Biophys. J., 45, 165 (1984).

    Article  CAS  Google Scholar 

  47. M.B. Jackson, Proc. Natl. Acad. Sci, U.S.A., 81, 3901 (1984).

    Article  CAS  Google Scholar 

  48. H.W. Chang and E. Neumann, Proc. Natl. Acad. Sci, U.S.A., 73, 3364 (1976).

    Article  CAS  Google Scholar 

  49. M.A. Raftery, J. Schmidt and D.G. Clark, Arch. Biochem. Biophys., 152, 882 (1972).

    Article  CAS  Google Scholar 

  50. J.A. Dani, Biophys. J., 49, 607 (1986).

    Article  CAS  Google Scholar 

  51. K. Imoto, C. Busch, B. Sakmann, M. Mishina, T. Konno, J. Nakai, H. Bujo, Y. Mori, K. Fu Uka and S. Numa, Nature (London), 334, 645 (1988).

    Article  Google Scholar 

  52. J.A. Dani and G. Eisenman, J. Gen. Physiol., 89, 959 (1987).

    Article  CAS  Google Scholar 

  53. C. Toyoshima and N. Unwin, Nature (London), 336, 247 (1988).

    Article  CAS  Google Scholar 

  54. H. Schindler and U. Quast, Proc. Natl. Acad. Sci. U.S.A., 70, 3052 (1980).

    Article  Google Scholar 

  55. O.P. Hamill and B. Sakmann, Nature (London), 294, 462 (1981).

    Article  CAS  Google Scholar 

  56. C. Methfessel, V. Witzemann, T. Takahashi, M. Mishina, S. Numa and B. Sakmann, Pflügers Arch., 407, 577 (1986).

    Article  CAS  Google Scholar 

  57. E. Yeramian, A. Trautmann and P. Claverie, Biophys. J., 50, 253 (1986).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Plenum Press, New York

About this chapter

Cite this chapter

Neumann, E., Schürholz, T. (1994). The Electrochemical Signal Transmission by the Acetylcholine Receptor: Single Channel Conductance Events and Oligochannels. In: Melandri, B.A., Milazzo, G., Blank, M. (eds) Bioelectrochemistry IV. NATO ASI Series, vol 267. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2576-9_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2576-9_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44813-3

  • Online ISBN: 978-1-4615-2576-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics