The Effects of Airway CO2 and Cooling on Ventilation and Upper Airway Resistance in Anaesthetized Rats

  • Aidan K. Curran
  • Kenneth D. O’Halloran
  • Aidan Bradford
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 360)


Upper airway (UA) luminal CO2 modulates the activity of superior laryngeal nerve afferents (Boushey et al, 1974, Bradford et al, 1990) and affects breathing and UA muscle activity through a superior laryngeal nerve-mediated reflex (Nolan et al, 1990) Therefore, airway CO2 may influence the patency of the UA, especially in obstructive apnoea and other circumstances of altered UA CO2 concentration However, the effects of UA luminal CO2 on airway patency have not been studied


Mucosal Blood Flow Superior Laryngeal Nerve Motor Nerve Activity Expiratory Time Peak Inspiratory Flow 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Aidan K. Curran
    • 1
  • Kenneth D. O’Halloran
    • 1
  • Aidan Bradford
    • 1
  1. 1.Department of PhysiologyRoyal College of Surgeons in IrelandDublin 2Ireland

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