Fetal Reflexes in Chronic Hypoxaemia

  • Laura Bennet
  • Takanori Watanabe
  • John Spencer
  • Mark A. Hanson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 360)

Abstract

Currently our physiological and clinical understanding of how the fetus responds to hypoxaemia or asphyxia is primarily based on observations of the effects of single acute episodes of these insults. We know very little about how the fetus responds and adapts to chronic hypoxaemia or asphyxia, yet it is becoming increasingly evident that the developing fetus is more likely to face either such continuous compromise or repeated acute insults. It is evident from a number of studies that what happens during fetal life has important consequences after birth. This observation raises several fundamental questions about how the fetus adapts to its abnormal intrauterine environment, how it is able to respond to further challenges and how these fetal adaptations affect postnatal life.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bocking, A.D., White, S.E., Gagnon, R. & Hansford, H. (1989) Effect of prolonged hypoxemia on fetal heart rate accelerations and decelerations in sheep. Am.J. Obst. Gynaecol. 161: 722–7.Google Scholar
  2. Bocking, A.D. (1993) Effects of chronic hypoxaemia on circulatory control, In “Fetus and Neonate Physiology and Clinical Applications.”, Volume 1, The Circulation, M.A. Hanson, J.A.D. Spencer, C.H. Rodeck, eds., Cambridge University Press, Cambridge.Google Scholar
  3. Hooper, S.B., Bocking, A.D., White, S.E., Challis, J.R.G. & Han, V.K.M. (1991) Changes in lung liquid dynamics induced by prolonged hypoxaemia. Am.J.Physiol. 261: R508–R514.PubMedGoogle Scholar
  4. Kitanaka, T., Alonso, J.G., Gilbert, R.D., Benjamin, L.S., Clemons, G.K. & Longo, L.D. (1989) Fetal responses to long-term hypoxemia in sheep. Am. J. Physiol. 256: R1348–R1354.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Laura Bennet
    • 1
  • Takanori Watanabe
    • 1
  • John Spencer
    • 1
  • Mark A. Hanson
    • 1
  1. 1.Department of Obstetrics and GynaecologyUniversity College London Medical SchoolLondonUK

Personalised recommendations