Metabolic Acid-Base Status and the Role of Carotid Chemoreceptors in Hyperoxic Breathing
There is controversy as to how much the peripheral chemoreceptors may contribute to pulmonary ventilation during hyperoxia under normocapnic and hypercapnic conditions. Whereas cutting the carotid sinus nerves (CSN) is reported to considerably depress ventilation in cats (Katsaros, 1968, Berkenbosch et al., 1979), we did not find any significant effect of cutting or cooling the CSN in rabbits (Kiwull et al., 1972). It has to be questioned, whether the metabolic acid-base status under otherwise normal blood-gas conditions could be responsible for these discrepancies. To exclude feedback effects of spontaneous breathing, this study was carried out with artificial ventilation.
KeywordsAttenuation Respiration Bicarbonate Pentobarbital
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