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Metabolic Acid-Base Status and the Role of Carotid Chemoreceptors in Hyperoxic Breathing

  • Heidrun Kiwull-Schöne
  • Sabine Bungart
  • Peter Kiwull
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 360)

Abstract

There is controversy as to how much the peripheral chemoreceptors may contribute to pulmonary ventilation during hyperoxia under normocapnic and hypercapnic conditions. Whereas cutting the carotid sinus nerves (CSN) is reported to considerably depress ventilation in cats (Katsaros, 1968, Berkenbosch et al., 1979), we did not find any significant effect of cutting or cooling the CSN in rabbits (Kiwull et al., 1972). It has to be questioned, whether the metabolic acid-base status under otherwise normal blood-gas conditions could be responsible for these discrepancies. To exclude feedback effects of spontaneous breathing, this study was carried out with artificial ventilation.

Keywords

Metabolic Acidosis Spontaneous Breathing Artificial Ventilation Pulmonary Ventilation Germany Introduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Heidrun Kiwull-Schöne
    • 1
  • Sabine Bungart
    • 1
  • Peter Kiwull
    • 1
  1. 1.Department of PhysiologyRuhr-UniversityBochumGermany

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