Urokinase and its Receptor: Markers of Malignancy?
For many years it has been known that abnormal coagulation and fibrinolytic activity existed in the environs of malignant tumours. Whether these activities affected the invasiveness and metastatic activity of tumours has been in question for some time. The advent of precise assays for individual components of both coagulation and fibrinolysis has allowed a more precise analysis of the individual components of those systems which seem relevant to malignancy. While this report may not seem to fit ideally into an international meeting on Arterial Chemoreception it is felt that a wider perspective on receptors in disease may not go amiss. Thus we present herein a brief overview on the role of one component of the human fibrinolytic system, urinary-type plasminogen activator, uPA (also known as urokinase in the UK) and its receptor, called uPA receptor (e.g. u-PAR) in human malignancy. A brief comment is also given on a role for tissue plasminogen activator (tPA) in malignancy.
KeywordsBreast Cancer Breast Tumour Tissue Plasminogen Activator Fibrinolytic Activity Disease Free Interval
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