Abstract
Although catecholamines are believed to be the primary chemosensory transmitters, acetylcholine (ACh) is also present in type I cells, and is released during stimulation of the carotid body (Eyzaguirre & Zapata, 1968; Fidone & Gonzalez, 1986). Effects of exogenous ACh vary with species (Fidone et al., 1990), but in the rat and cat, excitatory effects such as increased carotid sinus nerve activity or the stimulation of catecholamine release are observed (Shaw et al., 1989; Kholwadwala & Donnelly, 1992). These effects are mediated by nicotinic ACh receptors (nAChRs). Here, we have examined the actions of nicotinic agonists on isolated type I cells to determine whether nAChRs are present on these cells, and how their activation might lead to the reported excitation of the intact carotid body.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Buckler, K. J. &Vaughan-Jones, R. D. (1993). Effects of acidic stimuli on intracellular calcium in isolated type-I cells of the neonatal rat carotid body. Pflugers Archiv, (in press).
Chen, I. L. &Yates, R. D. (1984). Two types of glomus cell in the rat carotid body as revealed by alphabungarotoxin binding. J. Neurocytol. 13:281–302.
Eyzaguirre, C. &Zapata, P. (1968). The release of acetylcholine from carotid body tissues. Further study on the effects of acetylcholine and cholinergic blocking agents on the chemosensory discharge. J. Physiol. 195:589–607.
Fidone, S. &Gonzalez, C. (1986). Initiation and control of chemoreceptor activity in the carotid body. In The Respiratory System, Handbook of Physiology, Cherniack, N. S. &Widdicombe, J. G., eds, Sect. 3, vol. II, pp 247–312. American Physiological Society, Bethesda, MD.
Fidone, S., Gonzalez, C., Obeso, A., Gomez-Nino, A. &Dinger, B. (1990). Biogenic amine and neuropeptide transmitters in carotid body chemotransmission: experimental findings and perspectives. In Hypoxia: The Adaptations (eds Sutton, J. R., Coattes, G. &Remmers, J. E.) pp 116–126. Marcel-Decker, London.
Kholwadwala, D. &Donnelly, D. F. (1992). Maturation of carotid body chemoreceptor sensitivity to hypoxia: in vitro studies in the newborn rat. J. Physiol. 453:461–474.
Peers, C. (1991). Hypoxic suppression of K+ currents in type I carotid body cells: selective effect on the Ca2+-activated K+ current. Neurosci. Lett. 119:253–256.
Shaw, K., Montague, W. &Pallot, D. J. (1989). Biochemical studies on the release of catecholamines from the rat carotid body in vitro. Biochim. Biophys. Acta 1013:42–46.
Vernino, S., Amador, M., Luetje, C. W., Patrick, J. &Dani, J. A. (1992). Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8:127–134.
Wyatt, C. N. & Peers, C. (1993). Nicotinic acetylcholine receptors in isolated type I cells of the neonatal rat carotid body. Neurosci. 54:275–281.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Peers, C., Wyatt, C.N., Buckler, K.J. (1994). Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_17
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2572-1_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6099-5
Online ISBN: 978-1-4615-2572-1
eBook Packages: Springer Book Archive