Abstract
The importance of chemical stimuli in the regulation of pulmonary ventilation was well established by 1925, and the direct influence of carbon dioxide, oxygen and hydrogen ion concentration, alone or in combination, upon Flourens’ noeud vital (1842) was the widely accepted interpretation of the cross-circulation experiments reported by Leon Fredericq in 1901, which showed that changes in activity of the respiratory centre were induced by varying the carbon dioxide concentration in the blood supplied to the perfused head.
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Breathnach, C.S. (1994). A Belated Centennial Tribute to Corneille Heymans. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_13
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