Urolithiasis 2 pp 271-274 | Cite as

In Undiluted Human Urine Tamm-Horsfall Mucoprotein Mitigates the Promotion of Calcium Oxalate Crystallization Induced by Urate

  • P. K. Grover
  • V. R. Marshall
  • R. L. Ryall

Abstract

We have previously reported that dissolved urate promotes calcium oxalate (CaOx) crystallization by enhancing crystal nucleation, bulk deposition and aggregation1, 2. All these experiments were carried out either with spun and 0.22 µm filtered or 10 kDa ultrafiltered urines which are devoid of Tamm-Horsfall mucoprotein (THM). However, THM is a natural macromolecular component of whole urine and inhibits CaOx crystal aggregation3. Thus it is quite possible that the promotory effect of dissolved urate we observed may not necessarily occur in vivo where the protein is present in large amounts.

Keywords

Crystallization Oxalate HEPES Monohydrate Glycosaminoglycan 

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References

  1. 1.
    PK Grover, RL Ryall and VR Marshall, The effect of urate on calcium oxalate crystallization in human urine: Evidence for a promotory role of hyperuricosuria in urolithiasis, Clin Sci 79: 9 (1990).PubMedGoogle Scholar
  2. 2.
    PK Grover, RL Ryall and VR Marshall, Calcium oxalate crystallization in urine: The role of urate and glycosaminoglycans, Kidney Int 41: 149 (1992).PubMedCrossRefGoogle Scholar
  3. 3.
    PK Grover, RL Ryall and VR Marshall, Does Tamm-Horsfall mucoprotein inhibit or promote calcium oxalate crystallization in human urine? Clin Chim Acta 190: 223 (1990).PubMedCrossRefGoogle Scholar
  4. 4.
    RL Ryall, CM Hibberd and VR Marshall, A method for studying inhibitory activity in whole urine, Urol Res 13: 285 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • P. K. Grover
    • 1
  • V. R. Marshall
    • 1
  • R. L. Ryall
    • 1
  1. 1.Department of SurgeryFlinders Medical CentreBedford ParkAustralia

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