In Undiluted Human Urine Tamm-Horsfall Mucoprotein Mitigates the Promotion of Calcium Oxalate Crystallization Induced by Urate
We have previously reported that dissolved urate promotes calcium oxalate (CaOx) crystallization by enhancing crystal nucleation, bulk deposition and aggregation1, 2. All these experiments were carried out either with spun and 0.22 µm filtered or 10 kDa ultrafiltered urines which are devoid of Tamm-Horsfall mucoprotein (THM). However, THM is a natural macromolecular component of whole urine and inhibits CaOx crystal aggregation3. Thus it is quite possible that the promotory effect of dissolved urate we observed may not necessarily occur in vivo where the protein is present in large amounts.
KeywordsCrystallization Oxalate HEPES Monohydrate Glycosaminoglycan
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