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Effects of Glycosaminoglycans on Experimental Urolithiasis in Rats

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Urolithiasis 2

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Abstract

It has been suggested that the glycosaminoglycans (GAGs) heparan sulfate (HS) and chondroitin sulfate (CS) inhibit calcium oxalate (CaOx) crystallization in vitro 1. Moreover we have previously found that stone forming subjects excrete lower levels of GAGs compared to non-stone formers2. Thus, since GAGs may inhibit calculi growth in vivo, we tested the effect of administering CS to rats using an experimental model of lithiasis.

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References

  1. WG Robertson, M Peacock, BEC Nordin, Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro, Clin Chim Acta 43: 31 (1973).

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  2. YM Michelacci, RQ Clashan, N Schor, Urinary excretion of glycosaminoglycans in normal and stone forming subjects, Kidney Int 36: 1022 (1989).

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  3. JL Meyer, LH Smith, Growth of calcium oxalate crystals. I. Model of urinary stone growth. Invest Urol 13: 31 (1975).

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Author information

Authors and Affiliations

  1. Nephrology Division, Escola Paulista de Medicina, SP, Brazil

    M. A. Boim, C. T. Bergamaschi & N. Schor

  2. Department of Molecular Biology, Escola Paulista de Medicina, Brazil

    Y. M. Michelacci

Authors
  1. M. A. Boim
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  2. C. T. Bergamaschi
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  3. Y. M. Michelacci
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  4. N. Schor
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Editor information

Editors and Affiliations

  1. Flinders Medical Centre, South Australia, Australia

    Rosemary Ryall  & Villis R. Marshall  & 

  2. Institute of Medical and Veterinary Science, Adelaide, Australia

    Renze Bais  & Allan M. Rofe  & 

  3. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  4. University of British Columbia, Vancouver, British Columbia, Canada

    Valerie R. Walker

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© 1994 Springer Science+Business Media New York

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Boim, M.A., Bergamaschi, C.T., Michelacci, Y.M., Schor, N. (1994). Effects of Glycosaminoglycans on Experimental Urolithiasis in Rats. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_72

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  • DOI: https://doi.org/10.1007/978-1-4615-2556-1_72

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6091-9

  • Online ISBN: 978-1-4615-2556-1

  • eBook Packages: Springer Book Archive

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