Urolithiasis 2 pp 221-222 | Cite as

Effects of Glycosaminoglycans on Experimental Urolithiasis in Rats

  • M. A. Boim
  • C. T. Bergamaschi
  • Y. M. Michelacci
  • N. Schor

Abstract

It has been suggested that the glycosaminoglycans (GAGs) heparan sulfate (HS) and chondroitin sulfate (CS) inhibit calcium oxalate (CaOx) crystallization in vitro 1. Moreover we have previously found that stone forming subjects excrete lower levels of GAGs compared to non-stone formers2. Thus, since GAGs may inhibit calculi growth in vivo, we tested the effect of administering CS to rats using an experimental model of lithiasis.

Keywords

Crystallization Agarose Electrophoresis Oxalate Glycosaminoglycan 

References

  1. 1.
    WG Robertson, M Peacock, BEC Nordin, Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro, Clin Chim Acta 43: 31 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    YM Michelacci, RQ Clashan, N Schor, Urinary excretion of glycosaminoglycans in normal and stone forming subjects, Kidney Int 36: 1022 (1989).PubMedCrossRefGoogle Scholar
  3. 3.
    JL Meyer, LH Smith, Growth of calcium oxalate crystals. I. Model of urinary stone growth. Invest Urol 13: 31 (1975).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • M. A. Boim
    • 1
  • C. T. Bergamaschi
    • 1
  • Y. M. Michelacci
    • 2
  • N. Schor
    • 1
  1. 1.Nephrology DivisionEscola Paulista de MedicinaBrazil
  2. 2.Department of Molecular BiologyEscola Paulista de MedicinaBrazil

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