Effects of Glycosaminoglycans on Experimental Urolithiasis in Rats
It has been suggested that the glycosaminoglycans (GAGs) heparan sulfate (HS) and chondroitin sulfate (CS) inhibit calcium oxalate (CaOx) crystallization in vitro 1. Moreover we have previously found that stone forming subjects excrete lower levels of GAGs compared to non-stone formers2. Thus, since GAGs may inhibit calculi growth in vivo, we tested the effect of administering CS to rats using an experimental model of lithiasis.
KeywordsCrystallization Agarose Electrophoresis Oxalate Glycosaminoglycan