Urinary Glycosaminoglycans Differ in their Calcium Oxalate Crystallization Activities
Various studies have indicated that urinary macromolecules exhibit diverse activities towards calcium oxalate crystallization1, 2. One group of these macromolecules, the glycosaminoglycans (GAGs), has been shown to affect calcium oxalate crystallization3, 4. Our interest in GAGs stems from previous evidence that urinary polyanions exhibit differences towards crystallization of urinary calcium oxalate between normal controls and stone-formers5 and further to this, Reference standard GAGs (obtained from non-urinary sources) appear to behave differently from urinary GAGs6. The present study indicates that urinary GAG classes from normals and stone formers influence crystallization differently, though electrophoretically they appear similar.
KeywordsHeparan Sulphate Calcium Oxalate Calcium Oxalate Crystal Uronic Acid Content Barium Acetate
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