Enhancement of Urinary Oxalate Excretion by Vitamin C: Fact or Artifact ?
Oxalate is considered to be a major end-product of ascorbic acid metabolism. Self administration of gram amounts of vitamin C for prophylaxis and treatment of various diseases is very common. There are conflicting reports of hyperoxaluria due to the ingestion of megadoses of vitamin C5. Part of the confusion seems to be due to interferences of ascorbate with assay procedures for oxalate1-4. In the present study with high intake of vitamin C we compared urinary oxalate values before and after enzymatic elimination of ascorbate.
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