Urolithiasis 2 pp 133-135 | Cite as

Enhancement of Urinary Oxalate Excretion by Vitamin C: Fact or Artifact ?

  • M. Butz
  • M. Kaiser
  • R. Fitzner


Oxalate is considered to be a major end-product of ascorbic acid metabolism. Self administration of gram amounts of vitamin C for prophylaxis and treatment of various diseases is very common. There are conflicting reports of hyperoxaluria due to the ingestion of megadoses of vitamin C5. Part of the confusion seems to be due to interferences of ascorbate with assay procedures for oxalate1-4. In the present study with high intake of vitamin C we compared urinary oxalate values before and after enzymatic elimination of ascorbate.


Calcium Oxalate Urinary Oxalate Ascorbate Oxidase Oxalate Excretion Urinary Oxalate Excretion 
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  1. 1.
    CS Tsao, SL Salimi, Effect of large intake of ascorbic acid on urinary and plasma oxalic acid levels. Internal J Vit Nutr Res 54, 245–249 (1984).Google Scholar
  2. 2.
    RAJ Conyers, R Bais, AM Rofe, N Potezny, DW Thomas, Ascorbic acid intake, renal function, and urinary oxalate excretion. Aust NZ J Med 25, 353–355 (1985).CrossRefGoogle Scholar
  3. 3.
    KV Inamdar, KG Raghavan, DS Pradhan, Five treatment procedures evaluated for the elimination of ascorbate interference in the enzymatic determination of urinary oxalate. Clin Chem 37, 384–868 (1991).Google Scholar
  4. 4.
    BC Mazzachi, JK Teubner, RL Ryall, Factors affecting measurement of urinary oxalate, Clin Chem 30, 1339–1343 (1984).PubMedGoogle Scholar
  5. 5.
    IS Parkinson, WL Sheldon, MF Laker, PA Smith, Critical evaluation of a commercial enzyme kit (Sigma) for determining oxalate concentrations in urine. Clin Chem 33, 1203–1207 (1987).PubMedGoogle Scholar
  6. 6.
    JM Rivers. Safety of high level vitamin C ingestion, Ann NY Acad Sci 498, 445–454 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • M. Butz
    • 1
  • M. Kaiser
    • 1
  • R. Fitzner
    • 2
  1. 1.Urology DeptJoseph HospitalPaderbornGermany
  2. 2.Inst. Clinical ChemistryKlinikum Steglitz, FUBerlinGermany

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