Skip to main content
SpringerLink
Log in

Renal Handling of Citrate in Patients with Primary Hyperparathyroidism and Calcium Nephrolithiasis

  • Chapter
Urolithiasis 2

  • 21 Accesses

Abstract

The risk of calcium stone formation in the course of primary hyperparathyroidism (PHPT) is known to arise from increases in excretion of promoters such as calcium1, phosphate2 and perhaps oxalate. In contrast, the role of inhibitors has so far received less attention and very little is known about citrate, which is a main inhibitor of calcium salt crystallization in urine. Therefore, we have studied patterns of citrate excretion and renal handling in patients with PHPT and calcium nephrolithiasis and their changes after successful parathyroidectomy (PTX).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. AE Broadus, Primary hyperparathyroidism, J Urol 141 723 (1989).

    PubMed  CAS  Google Scholar 

  2. CYC Pak, MJ Nicar, R Peterson, A Zerwekh and W Snyder, A lack of unique pathophysiologic background for nephrolithiasis of primary hyperparathyroidism, J Clin Endocrinol Metab 53 536 (1981).

    Article  PubMed  CAS  Google Scholar 

  3. M Marangella, C Vitale, D Cosseddu, C Martini, M Petrarulo, F Linari, Renal handling of citrate in chronic renal insufficiency, Nephron 57: 439 (1991).

    Article  PubMed  CAS  Google Scholar 

  4. A Hodgkinson, The relation between citric acid and calcium metabolism with particular Reference to PHPT and idiopathic hypercalciuria, Clin Sci 24: 167 (1963).

    PubMed  CAS  Google Scholar 

  5. MJ Nicar, C Skurla, K Sakhaee, CYC Pak, Low urinary citrate excretion in nephrolithiasis, Urology 21: 8 (1983).

    Article  PubMed  CAS  Google Scholar 

  6. S Ljunghall, BG Danielson, G Johansson and L Wibell, Renal stone formation in PHPT. Role of tubular disfunction, in “Urolithiasis”, Springer Science+Business Media New York (1981).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Renal Stone Laboratory, Mauriziano Umberto I Hospital, Turin, Italy

    M. Marangella, C. Vitale, D. Cosseddu, M. Bruno, A. Tricerri, M. Manganaro & F. Linari

Authors
  1. M. Marangella
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Vitale
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Cosseddu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Bruno
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Tricerri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Manganaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. Linari
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Flinders Medical Centre, South Australia, Australia

    Rosemary Ryall  & Villis R. Marshall  & 

  2. Institute of Medical and Veterinary Science, Adelaide, Australia

    Renze Bais  & Allan M. Rofe  & 

  3. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  4. University of British Columbia, Vancouver, British Columbia, Canada

    Valerie R. Walker

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Marangella, M. et al. (1994). Renal Handling of Citrate in Patients with Primary Hyperparathyroidism and Calcium Nephrolithiasis. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_241

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2556-1_241

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6091-9

  • Online ISBN: 978-1-4615-2556-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation