Endogenous Synthesis of Oxalate in Magnesium Deficient Weanling Rats
Magnesium is a risk factor in urolithiasis. Studies have demonstrated the depressive effect of magnesium on endogenous oxalic acid formation1. Hypomagnesuria is a very common finding amongst stone formers2. A subclinical magnesium deficiency has been reported amongst general population from affluent countries, as the dietary intake of magnesium from the prepared meals is far below the recommended dietary allowance3. Although several experimental studies have shown a positive relationship between dietary and urinary magnesium and stone formation, the detailed biochemical mechanisms underlying magnesium deficiency has not been worked out. Therefore, the present study was carried out to clearly elucidate the effect of magnesium deficiency on endogenous synthesis of oxalate in liver as well as kidney in male weanling rats.
KeywordsCalcium Oxalate Magnesium Deficiency Endogenous Synthesis Calcium Oxalate Monohydrate Kidney Mitochondrion
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