Skip to main content

Endogenous Synthesis of Oxalate in Magnesium Deficient Weanling Rats

  • Chapter
Urolithiasis 2
  • 23 Accesses

Abstract

Magnesium is a risk factor in urolithiasis. Studies have demonstrated the depressive effect of magnesium on endogenous oxalic acid formation1. Hypomagnesuria is a very common finding amongst stone formers2. A subclinical magnesium deficiency has been reported amongst general population from affluent countries, as the dietary intake of magnesium from the prepared meals is far below the recommended dietary allowance3. Although several experimental studies have shown a positive relationship between dietary and urinary magnesium and stone formation, the detailed biochemical mechanisms underlying magnesium deficiency has not been worked out. Therefore, the present study was carried out to clearly elucidate the effect of magnesium deficiency on endogenous synthesis of oxalate in liver as well as kidney in male weanling rats.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. P Brundig, W Berg and HJ Schneider, The influence of magnesium chloride on blood and urine parameters in calcium oxalate stone patients, Eur Urol 7: 97 (1981).

    PubMed  CAS  Google Scholar 

  2. D Wangoo, V Rattan, SK Thind, GS Gupta and R Nath, Orcadian rhythmicity in the urinary excretion of metallic ions (Mg, Cu, Fe and Zn) amongst stone formers (SF) and non-stone formers (NSF) in North-Western India (Abstract), Magnesium Res 4: 211 (1991).

    Google Scholar 

  3. M Abdulla and F Reis, How adequate is the dietary intake of magnesium from a global point of view? (Abstract), Magnesium Res 4: 248 (1991).

    Google Scholar 

  4. V Rattan, D Wangoo, HK Koul and SK Thind, Urinary excretion of lithogens and inhibitory activity towards calcium oxalate monohydrate crystallization in vitamin A deficient rats, in: “Urolithiasis Research,” R Nath and SK Thind, ed, Ashish Publishers, New Delhi, India (1989).

    Google Scholar 

  5. S Sharma, H Sidhu, R Narula, SK Thind and R Nath, Comparative studies on the effect of Vitamin A, B, and B6 deficiency on oxalate metabolism in male rats, Ann Nutr Metab 34: 104 (1990).

    Article  PubMed  CAS  Google Scholar 

  6. H Sidhu, R Gupta, SK Thind and R Nath, Oxalate metabolism in thiamine-deficient rats, Ann Nutr Metab 31: 354 (1987).

    Article  PubMed  CAS  Google Scholar 

  7. H Barnett, The staining of lactate dehydrogenase isoenzymes: Electrophoretic separation on cellulose acetate, J Clin Path 17: 567 (1964).

    Article  PubMed  CAS  Google Scholar 

  8. MA Schlossberg, RJ Bloom, DA Richert and WW Westerfield, Carboligase activity of oα,-KG dehydrogenase, Biochemistry 9: 1148 (1970).

    Article  PubMed  CAS  Google Scholar 

  9. EE Dekker and SC Gupta, Oxidation of L-2 keto-4hydroxyglutarate to malyl-CoA by α-ketoglutarate dehydrogenase and its role in a pyruvate catalyzed glyoxylate oxidation cycle (Abstract), Fed Proc 38: 2339 (1979).

    Google Scholar 

  10. SR Grady, JK Wang and EE Dekker, Steady state kinetics and inhibition studies of aldol condensation reaction catalyzed by bovine liver and E. Coli 2-keto-4hydroxyglutarate aldolase, Biochemistry 20: 2497 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. A Adinolfi, S Oilezza and A Ruffo, Inhibition of oxoglutarate dehydrogenase by glyoxylate and its condensation compounds, J Biochem 104: 50p (1967).

    Google Scholar 

  12. Y Itokawa, K Inoue, Y Notori, K Okazaki and M Fujiwara, Effect of thiamine on growth, tissue magnesium, thiamine levels and transketolase activity in magnesium — deficient rats, J Vitaminol 18: 159 (1972).

    Article  CAS  Google Scholar 

  13. J Everse and NO Kaplan, Lactate dehydrogenase: Structure and function, Adv Enzymol 37: 61 (1973).

    PubMed  CAS  Google Scholar 

  14. FW Heaton and JP Elie, Metabolic activity of liver mitochondria from magnesium-deficient rats, Magnesium Exp Clin Res 3: 21 (1984).

    CAS  Google Scholar 

  15. EJ Brush and GA Hamilton, Thiol-glyoxalate adducts as substrates for rat kidney L-α-hydroxy acid oxidasc, Biochem Biophys Res Commun 103: 1194 (1981).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Rattan, V., Thind, S.K., Jethi, R.K., Nath, R. (1994). Endogenous Synthesis of Oxalate in Magnesium Deficient Weanling Rats. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2556-1_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6091-9

  • Online ISBN: 978-1-4615-2556-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics