Abstract
As reviewed by several authors, 1,2 ample evidence has been gathered over the past two decades to postulate a central role for specific receptors in transferrin-mediated iron metabolism of eukaryotic cells. These trypsin-sensitive3 glycoprotein dimers attract diferric transferrin (2Fe-Tf) from the extracellular fluid for endocytosis, followed by the release of iron in an intracellular location and return of both receptor and iron-free Tf (apo Tf) to the plasmalemma. Many observations, mainly on various hematopoietic cell lines, support the existence of an iron acquisition mechanism as just outlined.
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Regoeczi, E., Hu, WL., Chindemi, P.A., Janicka, M. (1994). The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages. In: Hershko, C., Konijn, A.M., Aisen, P. (eds) Progress in Iron Research. Advances in Experimental Medicine and Biology, vol 356. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2554-7_5
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DOI: https://doi.org/10.1007/978-1-4615-2554-7_5
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