Iron Overload and the Biliary Route
Iron, like other metals, is not destroyed within the body and therefore, in order to limit its biological and/or toxic effects, must be eliminated. Various elimination pathways exist physiologically, ensuring a balance with the amount of iron absorbed by the intestine, Le.1 to 2 mg per day corresponding to about 10 per cent of a normal diet containing 10-20 mg of iron 1. Iron losses occur mainly through exfoliated intestinal epithelial cells, smaller amounts being lost via the skin (desquamated cells and sweat) or by urinary route (0.1 mg daily). The biliary elimination of iron has classically been considered as a minor pathway. However, recent data from both human and experimental studies emphasize the importance of the biliary excretion route.
KeywordsCholesterol Carbohydrate Carbonyl Ferritin Transferrin
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- 1.P. Brissot and Y. Deugnier, Normal iron metabolism. Oxford Textbook of Clinical Hepatology, Ed. N Mclntyre, JP Benhamou, J Bircher, M Rizzetto and J Rodes, Oxford University Press 221 (1991).Google Scholar
- 2.R. Green, R. Charlton, H. Seftel, T. Bothwell, F. Mayet, B. Adams, C. Finch, and M. Layrisse, Body iron excretion in man, A collaborative study, Am J Physiol 45: 336 (1968).Google Scholar
- 7.N.F. LaRusso, Proteins in bile: how they get there and what they do, Am J Physiol 247: G 199 (1984).Google Scholar
- 11.P.J. Scheuer. Liver biopsy interpretation. 2nd ed. London: Baillère. Tindall and Cassell 1977.Google Scholar
- 12.Y.M. Deugnier, A.F. Rabot, R. Moirand, D. Le Quilleuc, D. Guyader, C. Jacquelinet, B. Turlin, and P. Brissot, Serum increase and liver overexpression of the carbohydrate 19.9 antigen in patients with untreated genetic hemochromatosis, Abst 4th International Conference on hemochromatosisi and Clinical Problems in Iron Metabolism, Jerusalem (April 27-May 1, 1993).Google Scholar
- 14.P. Brissot, J. Farjanel, D. Bourel, J.P. Campion,Guillouzo, A. Rattner, Y. Deugnier, B. Desvergne, B. Ferrand, M. Simon, and M. Bourel, Chronic liver iron overload in the baboon by ferric nitrilotriacetate. Morphologic and functional changes with special emphasis to collagen synthesis enzymes, Dig Dis Sci 32: 620 (1987).PubMedCrossRefGoogle Scholar
- 25.P. Brissot, G. Zanninelli, D. Guyader, J. Zeind, and J. Gollan, Biliary excretion of plasma non-transferrin-bound iron: a significant excretory pathway in normal but not in chronically iron overloaded rats, Am J Physiol (in press).Google Scholar